Results 41 to 50 of about 1,509,749 (267)

Sickle Cell Disease in Children and Adolescents: A Review of the Historical, Clinical, and Public Health Perspective of Sub-Saharan Africa and Beyond

International Journal of Pediatrics, 2022
Sickle cell disease (SCD) is an umbrella term for a group of life-long debilitating autosomal recessive disorders that are caused by a single-point mutation (Glu→Val) that results in polymerization of hemoglobin (Hb) and reversible sickle-shape ...
Walufu Ivan Egesa, Gloria Nakalema, William M. Waibi, Munanura Turyasiima, Emmanuel Amuje, Gloria Kiconco, Simon Odoch, Patrick Kumbowi Kumbakulu, Said Abdirashid, Daniel Asiimwe   +9 more
doaj   +1 more source

Supporting Survivor‐Centered Care Through Digital Health Integration

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Survivors of childhood cancer face barriers to receiving guideline‐based, long‐term follow‐up care. Two digital tools, Passport for Care (PFC) and Cancer SurvivorLink (SurvivorLink), address complementary gaps by enabling tailored survivorship care plan (SCP) generation, updating, storage, and sharing.
Jordan G. Marchak, Rebecca Williamson‐Lewis, Michael O'Connor, Michael Palgon, Yu‐Ra Kim, Michael Schuckenbrock, Paula Edwards, Abraham Mendoza, Anthony Adams, Brian Arriaga‐Solis, Justin Parker, Harry Tinoco‐Giraldo, Jason King, C. Michael Fordis, Karen E. Effinger, Maria Monica Gramatges   +15 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Integrating child eye health within primary health care: a case study

Community Eye Health Journal, 2018
Few children have access to specialised eye care in Tanzania. However, ten simple activities have been shown to reduce the risk of childhood blindness and eye disease dramatically.
Milka Mafwiri, Aeesha NJ Malik, Clare Gilbert   +2 more
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Evolution of pneumococcal serotype 19A in children in Bangladesh: insights from genomic analysis

BMC Microbiology
Background Invasive pneumococcal disease (IPD), caused by Streptococcus pneumoniae, remains a major global health concern, particularly for children.
Arif Mohammad Tanmoy, Esha Kazi, Naito Kanon, Hafizur Rahman, Harry C.H. Hung, Md Hasanuzzaman, Roly Malaker, Apurba Rajib Malaker, Deb Purna Keya, Sudipta Deb Nath, Belal Hossain, Shampa Saha, Mohammad Jamal Uddin, Lesley McGee, Stephen D. Bentley, Stephanie W. Lo, Yogesh Hooda, Samir K. Saha, Senjuti Saha   +18 more
doaj   +1 more source

Epidemiology and risk factors for pneumonia severity and mortality in Bangladeshi children <5 years of age before 10-valent pneumococcal conjugate vaccine introduction

BMC Public Health, 2016
Background Pneumonia is the leading infectious cause of morbidity and mortality in young children in Bangladesh. We present the epidemiology of pneumonia in Bangladeshi children
Shampa Saha, Md Hasan, Lindsay Kim, Jennifer L. Farrar, Belal Hossain, Maksuda Islam, ASM Nawshad Uddin Ahmed, M. Ruhul Amin, Mohammed Hanif, Manzoor Hussain, Shams El-Arifeen, Cynthia G. Whitney, Samir K. Saha   +12 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Verklaringen en aanbevelingen voor de dalende vaccinatiegraad onder kinderen tot twee jaar: impact van de coronapandemie

JGZ
Inleiding:  Steeds minder ouders in Nederland laten hun kinderen tot twee jaar (volledig)  vaccineren. Het vertrouwen in vaccinaties na 2020 in Nederland is niet hersteld, zoals elders in Europa.
Claudia Vrijhof, Lisanne Vonk, Katharina Preuhs, Hilde van Keulen   +3 more
doaj   +1 more source