Results 71 to 80 of about 588,782 (251)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Turkish Journal of Nephrology, 2019 A 26-month-old girl who had acute renal failure after a major cardiac operation received an accidental 4-fold vancomycin dose. She was already on peritoneal dialysis when the error in vancomycin dose and high serum vancomycin levels were fi rst noticed ...
Alper SOYLU +3 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hereditary spherocytosis: Retrospective evaluation of 65 children
The Turkish Journal of Pediatrics, 2018 Hereditary spherocytosis (HS) is a common cause of congenital hemolytic anemia in Caucasians and it could be diagnosed at any age. The aim of this study is to examine the demographic characteristics, clinical features and laboratory findings of children
Ali Güngör +5 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Peer Bullying in the Preadolescent Stage: Frequency and Types of Bullying and the Affecting Factors
Journal of Pediatric Research, 2019 Aim:This study was conducted to determine the types, frequencies and the affecting factors of peer bullying among 6th, 7th, and 8th grade students of secondary schools in a city center in Cappadocia.Materials and Methods:A total of 3.059 students were ...
Zehra Çalışkan +6 more
doaj +1 more source
Journey of a girl child in India during health and disease [PDF]
Indian Pediatrics, 2015 Gender inequality can express as inequalities in several dimensions – survival, natality, facilities, ownership, sharing of household benefits and chores, and domestic violence. Inequality in gender of one type may lead to gender inequality of many other types.
openaire +2 more sources