Results 61 to 70 of about 1,883,644 (311)

The association between salivary oxytocin, age, and puberty in children with and without OCD

Scientific Reports
The oxytocin system has been thought to contribute to obsessive-compulsive disorder (OCD). Few studies, only involving adults, have investigated this hypothesis and have found inconsistent results regarding oxytocin system activity and OCD.
Anna-Rosa Cecilie Mora-Jensen, Line Katrine Harder Clemmensen, Manja Gersholm Grønberg, Eli R. Lebowitz, Daniel S. Quintana, Niklas Rye Jørgensen, Charlotte Sewerin Larsen, Lasse Kristoffer Bak, Gitte Lund Christensen, Linea Pretzmann, Valdemar Uhre, Sofie Heidenheim Christensen, Camilla Uhre, Nicoline Løcke Jepsen Korsbjerg, Christine Lykke Thoustrup, Julie Hagstrøm, Melanie Ritter, Kerstin Jessica Plessen, Anne Katrine Pagsberg, Nicole Nadine Lønfeldt   +19 more
doaj   +1 more source

Is better mentalization always the remedy? Mentalization and internalising symptoms of psychopathology in children and adolescents: a rapid scoping review

Nordic Psychology
Mentalization theory (MT) is an influential theoretical framework with deficits in mentalizing hypothesised to be a key transdiagnostic factor in the development and treatment of various psychopathologies.
Martin Skovsgaard Batenburg, Mette Bentz, Signe Holm Pedersen   +2 more
doaj   +1 more source

Systematic review of the Exploration, Preparation, Implementation, Sustainment (EPIS) framework

Implementation Science, 2019
Background Effective implementation of evidence-based practices (EBPs) remains a significant challenge. Numerous existing models and frameworks identify key factors and processes to facilitate implementation. However, there is a need to better understand
Joanna C. Moullin, Kelsey S. Dickson, Nicole A. Stadnick, Borsika Rabin, Gregory A. Aarons   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The effectiveness of mHealth interventions for maternal, newborn and child health in low- and middle-income countries:Protocol for a systematic review and meta-analysis [PDF]

, 2014
Rates of maternal, newborn and child (MNCH) mortality and morbidity are vastly greater in low– than in high–income countries and represent a major source of global health inequity.
Begg, Black, Chib, Dudley, Egger, Free, Free, Kerber, Labrique, Lund, Mwaniki, Noordam, Pande, Perry, Ronsmans, Tamrat, Tomlinson, Van Malderen, Wulf   +18 more
core   +7 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Research priorities in Norwegian child and adolescent health promotion and preventive services: an adapted James Lind Alliance approach

BMJ Open
Objective To partner with healthcare professionals and other stakeholders to identify top 10 research priorities within universal child and adolescent health promotion and disease preventive services.Design The study used an adapted James Lind Alliance ...
Heidi Holmen, Kirsti Riiser, Astrid Torbjørnsen, Tonje Lervold, Marit Dromnes Manvik, Marte Morken Høyland, Helene Saksvik Ringås, Hanne Nissen Bjørnsen   +7 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source