Results 51 to 60 of about 1,685,245 (303)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Conocimientos de cuidadores en salud pediátrica en niños internados en el Hospital Universitario de Santander, Bucaramanga, Colombia Knowledge of pediatric health caregivers in children into the Hospital Universitario de Santander, Bucaramanga, Colombia

Salud UIS, 2012
Introducción: La hospitalización debe representar para cuidadores, valor agregado al aumentar sus conocimientos sobre la enfermedad y prevención de enfermedades prevalentes de infancia, generando cambios de actitud hacia salud y enfermedad, disminuyendo ...
Fabio Alberto Navas Domínguez, Carolina Vargas Porras, Sandra Cristina Estévez Suárez   +2 more
doaj  

USE OF THERAPEUTIC TOYS IN NURSING CARE OF THE HOSPITALIZED CHILD WITH LEUKEMIA

Cogitare Enfermagem, 2012
This exploratory-descriptive qualitative research aimed to identify the nursing team’s knowledge concerning the use of therapeutic toys, discuss the benefits and specificities of its use, and propose its implantation.
Alexandra Souza, Luciane Favero
doaj   +1 more source

Rekindling the Sacred Fire for Children and Families

, 2019
This video describes the partnership between the Sun Lodge Village and Peguis Child and Family Services in Peguis First Nation, Manitoba. Together we are providing opportunities for families, youth, and children to find their way back to traditional ...
Peguis Child and Family Services, Sun Lodge Village, Peguis Child and Family Services, Organization:, Sun Lodge Village, Organization:   +3 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

O EFEITO DA UTILIZAÇÃO DO BRINQUEDO TERAPÊUTICO, PELA ENFERMEIRA PEDIATRA, SOBRE O COMPORTAMENTO DE CRIANÇAS RECÉM-HOSPITALIZADAS

Revista da Escola de Enfermagem da USP
O trabalho descreve a realização e os resultados de uma pesquisa experimental, executada entre crianças de 3 a 5 anos, recém-hospitalizadas, com utilização da técnica de brinquedo terapêutico.
Circéa Amalia Ribeiro
doaj   +1 more source

Here be dragons! Reconciling Indigenous and Western knowledge to improve Aboriginal child welfare

, 2007
The authors discuss the factors regarding the reconciliation movement in reconciling Indigenous and Western Knowledge to improve child welfare practice with respect to Aboriginal peoples.
Bastien, Betty, LaFrance, Jean
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Understanding child neglect [PDF]

, 2014
Child neglect is one of the most common forms of maltreatment. Neglect is a topic that encompasses complex issues, many of which are also emerging research areas. This paper aims to provide a broad overview of these issues in relation to current thinking
Debbie Scott
core