Results 61 to 70 of about 1,685,245 (303)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

THE PARENTS’ KNOWLEDGE ON THE CARE PROCESS THROUGH PLAY

Cogitare Enfermagem, 2018
Objective: verify how the parents and/or legal caregivers of hospitalized children perceive playing as a dimension of Nursing care. Method: qualitative, descriptive, exploratory and prospective study, using theme/category-based analysis. A semistructured
Aderlaine da Silva Sabino, Arinete Véras Fontes Esteves, Ana Paula Pessoa de Oliveira, Marcos Vinícius Gusmão da Silva   +3 more
doaj   +1 more source

Child psychiatric hospitalizations in the Brazilian public health system: an exploratory study

Trends in Psychiatry and Psychotherapy, 2020
Objective To describe the characteristics and rates of child psychiatric hospitalizations in the Brazilian public health system, as well as their variation according to the country’s macro-regions. Methods This was a descriptive study focusing on year
Maximiliano Loiola Ponte de Souza, Rossano Cabral Lima   +1 more
doaj   +1 more source

Reflections of a Mi’kmaq social worker on a quarter of a century work in First Nations child welfare

, 2007
First Nations people would argue that the ‘Sixties Scoop’ of removing their children from their homes and culture never ended. First Nations children entering ‘care’ of child welfare agencies has increased significantly since the 1960s and 1970s. Storying
MacDonald, Nancy, MacDonald, Judy
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Estimation of the national disease burden of influenza-associated severe acute respiratory illness in Kenya and Guatemala : a novel methodology [PDF]

, 2013
Background: Knowing the national disease burden of severe influenza in low-income countries can inform policy decisions around influenza treatment and prevention.
Njuguna Henry, Mott, Joshua A., Kim A. Lindblade (265496), Henry Njuguna, Marc-Alain Widdowson, Mwanajuma Ngama (132330), Sonja J Olsen, Kim A Lindblade, Katz Mark A., Sidi Kazungu (382842), Joshua A. Mott (382843), Summers Aimee, McCracken John, Wences Arvelo, Sammy Khagayi, John McCracken, Khagayi Sammy, Kazungu Sidi, Aimee Summers (382838), Fuller James A., Marc-Alain Widdowson (123352), D. James Nokes (68994), Daniel R. Feikin (153640), Njuguna, Henry, Fuller, James A., Ngama, Mwanajuma, Daniel R Feikin, Joshua A Mott, Emukule Gideon, Sonja J. Olsen (226208), McCracken, John, Mark A. Katz (310324), Wences Arvelo (358137), Kazungu, Sidi, Mark A Katz, Nivaldo Linares-Perez, Nivaldo Linares-Perez (382840), Nokes D. James, Katz, Mark A., Mott Joshua A., Arvelo Wences, Sidi Kazungu, Olsen Sonja J., Summers, Aimee, Feikin, Daniel R., Olsen, Sonja J., Mwanajuma Ngama, Henry Njuguna (319757), Lindblade Kim A., James A Fuller, John McCracken (382841), Gideon Emukule, James A. Fuller (382837), Linares-Perez Nivaldo, Nokes, D. James, Arvelo, Wences, Emukule, Gideon, Gideon Emukule (336782), Widdowson Marc-Alain, D James Nokes, Linares-Perez, Nivaldo, Khagayi, Sammy, Ngama Mwanajuma, Aimee Summers, Sammy Khagayi (382839), Widdowson, Marc-Alain, Lindblade, Kim A., Feikin Daniel R.   +67 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

EPIDEMIOLOGY AND RISKS ASSOCIATED WITH PRESSURE ULCERS IN CHILDREN

Cogitare Enfermagem, 2011
This epidemiological transversal study aimed to identify the risk of, and factors associated with, the development of pressure ulcers in children hospitalized in a Pediatric Intensive Therapy Unit.
Georgea Bezerra Carvalho, Francisca Alexandra Araújo da Silva, Maria Euridéa de Castro, Raquel Sampaio Florêncio   +3 more
doaj   +1 more source