Results 31 to 40 of about 578 (190)

Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

Genes and Diseases
Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier function. Short-chain fatty acids (SCFAs), as metabolites of the gut microbiota, protect the physiological intestinal barrier; however, they are compromised when
Junyan Yan, Lu Xiao, Di Feng, Baolin Chen, Ting Yang, Bei Tong, Ruifang Luo, Yuting Wang, Jie Chen   +8 more
doaj   +1 more source

Well-controlled gestational diabetes mellitus without pharmacologic therapy decelerates weight gain in infancy

Frontiers in Endocrinology, 2022
AimThere are no prospective longitudinal studies on the association between well-controlled gestational diabetes mellitus (GDM) without pharmacologic therapy and the physical growth of offspring in infancy.
Chao Li, Chao Li, Chao Li, Yixi Cai, Yinying Li, Bin Peng, Yongfang Liu, Yongfang Liu, Zhenming Wang, Ting Yang, Ting Yang, Yirong Hu, Yajun Fu, Tingmei Shi, Hong Peng, Yue Zhang, Jie Chen, Jie Chen, Tingyu Li, Tingyu Li, Li Chen, Li Chen   +21 more
doaj   +1 more source

The value of intellectual structural imbalance in the differentiation of autism spectrum disorder and attention deficit hyperactivity disorder

Frontiers in Psychiatry
BackgroundThe study delves into the intricate task of differentiating intellectual structures among children diagnosed with the high-functioning Autism Spectrum Disorder (HF-ASD), Attention Deficit Hyperactivity Disorder (ADHD), or comorbidity (ASD+ADHD),
Dan-Yang Zhang, Qiu-Hong Wei, Bin-Yue Hu, Dan Ai, Yu Zhang, Yuan Ding, Ting Yang, Jie Chen, Li Chen, Yuan Wu, Hong-Yu Chen, Xue-Li Xiang, Qiu-Hong Mou, Ting-Yu Li   +13 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Social jet lag is associated with core symptoms in 2-3-year-old children with autism spectrum disorders

Frontiers in Psychiatry
BackgroundSocial jet lag (SJL) is a form of circadian rhythm misalignment caused by the mismatch between social schedules and biological clocks, which is associated with cognition, behavior, and emotion in children. However, social jet lag among children
Hongyu Chen, Ting Yang, Jie Chen, Yuan Ding, Yuan Ding, Xueli Xiang, Qiuhong Wei, Qiuhong Mou, Binlin Yuan, Binyue Hu, Danyang Zhang, Dan Ai, Tingyu Li, Tingyu Li   +13 more
doaj   +1 more source

Reference range of corpus callosum volume based on MRI data in typical development preschool children

陆军军医大学学报, 2022
Objective To investigate the change profiles in the volume of the corpus callosum (CC) among typical development preschool children of different ages and sexes based on the magnetic resonance imaging (MRI) data from normal volunteers.
ZHANG Yun, ZHANG Yun, WANG Longlun
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Vitamin A deficiency triggers colonic methylation potentially impairing colonic neuron via downregulation SGK1/FOXO pathway

Pediatric Discovery
DNA methylation is widely involved in the modification of intestinal function, but the methylation mechanism in the enteric nervous system has not been studied in vitamin A deficiency (VAD).
Bei Tong, Junyan Yan, Zhujun Sun, Ruifang Luo, Fang Lin, Riqiang Hu, Ting Yang, Yuting Wang, Jie Chen   +8 more
doaj   +1 more source

Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma

Frontiers in Psychiatry, 2022
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication difficulties, repetitive behaviors, and parochial interests.
Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Qiu Li, Qiu Li, Qiu Li, Qiu Li, Bin Peng, Yupeng Cun, Yupeng Cun, Yupeng Cun, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Yang Yu, Yang Yu, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Qiongli Fan, Yuping Zhang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Li Chen, Li Chen, Li Chen, Li Chen, Li Chen   +66 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source