Results 71 to 80 of about 113,034 (255)
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Child poverty and regional disparities in Turkey
The Turkish Journal of Pediatrics, 2013 The United Nations Children's Fund (UNICEF) defines child poverty as the inability of the child to realize their existing potential due to their inability to access resources across different dimensions of life (income, health, nutrition ...
Mehmet Ali Eryurt, Ismet Koç
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FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Türk Sinemasında Çocuk Yoksulluğu: “Zıkkımın Kökü” Filmi Örneği
Türkiye Film Araştırmaları Dergisi, 2022 Yoksulluk geçmişte olduğu gibi çağımızda da güncel temel problemler arasında yer alan bir olgudur. Yokluk hali ve yoksun olma hissi bireyin gündelik hayatta baş etmek zorunda kaldığı durumlardan biri olarak gösterilmektedir.
Ezgi Hazal Turhan
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Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Child Poverty: Concepts and Measurement [PDF]
حقوق بشر, 2008 This paper presents and discusses different concepts of child poverty, alternative definitions of children living in poverty, and measurement efforts in this regard. It addresses such questions as: who are the children living in poverty?
Alberto Minujin and Others
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Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Jeunes autochtones et protection de la jeunesse : leur point de vue sur leur prise en charge
Sociétés et Jeunesses en Difficulté, 2018 The overrepresentation of Aboriginal youth in child welfare services in Canada is a concerning reality. However, less is known of their experiences of child welfare services from their own perspective.
Marie-Hélène Gagnon Dion +2 more
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