Results 61 to 70 of about 1,377,555 (289)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

How can we talk about child protection without talking about child protection?

Child Protection and Practice
Language used by professionals when describing or speaking with parents of children within child protection services can be stigmatizing and harmful. Professionals across health, welfare and childhood education sectors frequently encounter parents who ...
Lauren Elizabeth Lines, Sarah Hunter, Amy Marshall, Tahlia Johnson, Megan Aston   +4 more
doaj   +1 more source

Child protection training in sport-related degrees amd initial teacher training for physical education: an audit [PDF]

, 2008
This article reports on the results of an online survey of child protection training for students on sport-related degrees and Initial Teacher Training Physical Education courses, and on the views of recently-graduated teachers of the usefulness of such ...
Brackenridge, CH, Rossato, C
core  

Improving practice : child protection as a systems problem [PDF]

, 2005
This paper argues for treating the task of improving the child protection services as a systems problem, and for adopting the system-focused approach to investigating errors that has been developed in areas of medicine and engineering where safety is a ...
Munro, Eileen
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Child Occupant Protection in Australia

Journal of Road Safety, 2012
Child occupants require special consideration in the motor vehicle, where the environment is largely engineered for adults. This paper reviews the issues that place child occupants in a special category and how these have been dealt with in Australia, as
Julie Brown, Lynne Bilston
doaj  

Measuring the impact of child protection through Activation States [PDF]

, 2005
Child protection (CP) has risen to the top of the UK sports policy agenda in the past four years and the Football Association has invested in this major strategy as part of its commitment to “use the power of football to build a better future” (FA, 2000a)
Brackenridge, CH, Bringer, JD, Cockburn, C, Nutt, G, Pawlaczek, Z, Pitchford, A, Russell, K   +6 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Examining Religious Leaders’ Engagement in Child Protection in Dzemeni, Volta Region, Ghana [PDF]

E-Journal of Humanities, Arts and Social Sciences
It is reported that ninety-four percent of children experience some form of abuse in Ghana. Where child abuse exists, an appropriate response is child protection.
Ebenezer Tetteh Kpalam, Emmanuel Nyarko-Tetteh, Eva Ahiataku   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source