Results 61 to 70 of about 1,385,409 (310)

Evaluating child protection [PDF]

Forced Migration Review, 2002
Recent allegations concerning the involvement ofhumanitarian workers in the sexual exploitation ofyoung people in West Africa have underlined theneed for more effective approaches to the protectionof refugee children.
doaj  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

THE CURRENT LANDSCAPE OF CHILD PROTECTION SERVICES IN SOUTH AFRICA: A SYSTEMATIC REVIEW

Social Work/Maatskaplike Werk, 2020
Child protection services are seen as the largest field of social work service delivery in South Africa. Repeated warnings of the ‘crisis state’ of child protection services have gone unheeded.
Marianne Strydom, Ulene Schiller, Julie Orme   +2 more
doaj   +1 more source

When it comes to safeguarding children, there exists a confused story about what we think maturity is [PDF]

, 2012
In the wake of the Rochdale grooming case and questions surrounding child protection in schools, Tim Linehan discusses our misconceptions around maturity and what this means for child safeguarding.
Linehan, Tim
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Child abuse, child protection and disabled children : a review of recent research [PDF]

, 2012
This paper reports the results of a scoping study which reviewed research about child abuse, child protection and disabled children published in academic journals between 1996 - 2009. The review was conducted using a five stage method for scoping studies.
Agnew, Akbas, Alderson, Aniol, Arksey, Balogh, Barnard, Briggs, Cederborg, Cederborg, Cooke, Firth, Giardino, Govindshenoy, Hershkowitz, Hollins, Jarosz, Jaudes, Jemta, Kapitanoff, Knutson, Kvam, Kvam, Kvam, Lightfoot, Manders, Mansell, Mitchell, Monahan, Morris, Reiter, Romney, Rosenberg, Ryan, Sequeira, Sequeira, Shannon, Sobsey, Spencer, Stalker, Sullivan, Sullivan, Westcott   +42 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The scale and timing of child protection system contacts from 0-18 years: a study of 1.9 million Australian children

International Journal of Population Data Science
Introduction To prevent abuse, neglect and poor outcomes for children and families, including child protection intervention, maltreatment, and removals, it is critical to understand the scale and timing of child protection system contacts to identify ...
Rhiannon Pilkington, Kathleen Falster, Mark Hanly, Alicia Montgomerie, Tasnia Ahmed, BJ Newton, Ben Edwards, Raghu Lingam, Anthony Shakeshaft, Michelle Cretikos, Jessica Stewart, Katherine Hawkins, Kitty McLean, John Lynch   +13 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Protect My Future: The Links Between Child Protection and Equity [PDF]

, 2012
The lack of care and protection facing children is a global crisis with billions of children experiencing abuse, neglect or exploitation, and many millions growing up outside of families, on the streets or in harmful institutional care.
Andy West, Emily Delap
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