Results 91 to 100 of about 989,369 (268)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Play is a child's work

, 2019
The aim of this study was to investigate the role of play for preschool children through an exploration and comparison of the views and perceptions of childcare practitioners and play therapists. There were three objectives in the study which were investigated and examined. The first objective was to establish the views and perceptions of professionals
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Exploring perceptions of genetic risk and the transmission of substance use disorders

Addiction Science & Clinical Practice
Background Substance use disorders (SUDs) have been consistently shown to exhibit moderate intergenerational continuity (1–3). While much research has examined genetic and social influences on addiction, less attention has been paid to clients’ and lay ...
Amanda Keller, Emily A. Bosk, Alicia Mendez, Brett Greenfield, Carolynn Flynn, Gina Everett (DelJones), Fabrys Julien, MacKenzie Michael   +7 more
doaj   +1 more source

Building Relational Permanence to Support the Transition to Adulthood Among System-Involved Youth

Adolescents
The transition to adulthood is challenging for all youth, but this developmental period can present substantial difficulties for youth involved in child-serving systems due to a constellation of adversities and a lack of protective factors present in ...
Cara Lucke, Kristine Piescher, Traci LaLiberte   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

教師工作結果與其工作情境因素之影響：以TEPS第三和第四波高中職教師調查

臺灣教育社會學研究, 2012
現代社會中工作情境和勞動者互動的結果，一直是為社會、組織和個人所關心的重要議題。本研究根據臺灣教育長期追蹤資料庫中第三和四波高中職教師資料，描述當前教師的工作結果樣貌，以及探索影響工作結果的情境因素，包含探討教育制度的特定影響，並檢證所提出之工作控制、要求和資源因素的組織情境解釋模型。在使用追蹤樣本的情境因素分析發現，高中職教師的倦怠、承諾、投入等工作結果皆偏向正面；而倦怠和組織承諾面向間存有顯著的負相關。學校外在制度性的公、私屬性和技職分流因素有穩定的影響，而學校組織情境的工作控制 ...
紀金山 Chin-Shan Chi
doaj  

Frontline Experiences of Newly Arrived Refugees in Norway and Denmark

Nordisk Välfärdsforskning
The article examines the experiences of Syrian and Ukrainian refugees in their encounters with municipal integration workers in Norway and Denmark.
Karen N. Breidahl, Anne Britt Djuve, Hanne C. Kavli, Christian Albrekt Larsen, Rasmus Sandy Harboesgaard Nielsen   +4 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Child Work Safety on the Farms of Local Agricultural Market Producers: Parent and Child Perspectives. [PDF]

J Agromedicine, 2018
Summers P, Quandt SA, Spears Johnson CR, Arcury TA.   +3 more
europepmc   +1 more source