Results 71 to 80 of about 989,369 (268)

Racial/ethnic differences in HIV testing: An application of the health services utilization model

open access: yesSAGE Open Medicine, 2018
This study applying the health services utilization model examined the importance of predisposing, enabling, and need variables to the social mechanisms explaining lifetime HIV testing across racial/ethnic groups. Data for the study were derived from the
Celia C Lo   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Empowerment, gender, and household dynamics in households receiving social cash transfers in Eastern and Southern Africa: evidence from a systematic review

open access: yesDevelopment Studies Research
Understanding the gendered intrahousehold dynamics of empowerment in social cash transfer programes is crucial for enhancing the effectiveness of programs in reducing poverty and promoting sustainable development. This systematic review draws on Kabeer’s
Cleopas Gabriel Sambo, Iselin Huseby-Lie
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

An Occupational Job Strain Index based on five Norwegian nationwide surveys of living conditions on work environment

open access: yesBMC Research Notes
Objectives This paper aims to provide comprehensive documentation of the Occupational Job Strain Index (JSI), developed using data from the Norwegian nationwide Survey of Living Conditions conducted in 2006, 2009, 2013, 2016, and 2019.
Åsmund Hermansen, Giang Huong Le
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Youths over 18 receiving support from the child welfare service: evolving motivation in the interaction between the youth and the caseworker

open access: yesNordic Social Work Research
This article focuses on the interaction between youths and caseworkers and how it influences youths’ motivation during emerging adulthood. The study is based on qualitative interviews with 10 youths aged 18–23 and six child welfare caseworkers.
Anne Riise, Veronika Paulsen
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

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