Results 61 to 70 of about 989,369 (268)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Oslo Law ReviewThis article examines the complex interplay between autonomy and paternalism in the domain of child welfare, with a special focus on the application of international human rights frameworks.
Merete Havre, Julia Köhler-Olsen
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
BMC Primary CareBackground Home visiting programs offer a way of delivering child health services to families that need them the most, based on socioeconomic and psychosocial conditions.
Maissa Al-Adhami +2 more
doaj +1 more source
Do Community Arts Programs Promote Positive Youth Development?
Critical Social Work, 2019 This study reports on the multi-method longitudinal examination of a structured arts program (combination of theatre, visual and media arts) for youth, aged 9 to 15 years, from a low-income community in Hillsborough County in Tampa, Florida.
Robin Wright +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
SocietiesResearch has highlighted racial and socioeconomic disparities for families in child welfare, with calls to address inequities through trainings and structural change. However, few measures have been developed to assess the recognition of racial and class
Monica Faulkner +3 more
doaj +1 more source