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The genetics of childhood cancer
Cancer, 1975Two classes of genes are apparently critical in the origin of the cancers of children. One class, that of oncogenes, acts by virtue of abnormal or elevated activity. It is operative primarily in leukemias and lymphomas. There is no evidence yet that genetic predisposition to these neoplasms can be imparted by oncogene mutations in the germline. However,
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Immunotherapies for Childhood Cancer
Cold Spring Harbor Perspectives in MedicineChildren are surviving cancer in greater numbers than ever. Over the last 50 years, substantial advancements in pediatric cancer treatment have resulted in an 85% 5-year survival rate. Nonetheless, a notable 10%-15% of patients encounter relapse or develop refractory disease, leading to significantly lower survival. Recent attempts to further intensify
Jeong A. Park, Nai-Kong V. Cheung
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Epidemiology of childhood cancer
Cancer Treatment Reviews, 2010The present contribution reports childhood cancer incidence and survival rates as well as time trends and geographical variation. The report is based on the databases of population-based cancer registries which joined forces in cooperative projects such as Automated Childhood Cancer Information System (ACCIS) and EUROCARE.
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JAMA: The Journal of the American Medical Association, 1985
To the Editor.— Miller and McKay 1 report a decline in US childhood mortality that they attribute "almost entirely" to improvements in therapy. That may be, but they offer no evidence to substantiate that claim. Indeed, there are strong reasons to conclude otherwise.
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To the Editor.— Miller and McKay 1 report a decline in US childhood mortality that they attribute "almost entirely" to improvements in therapy. That may be, but they offer no evidence to substantiate that claim. Indeed, there are strong reasons to conclude otherwise.
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Genitourinary cancer in childhood
Pediatric Nephrology, 1993R, Wammack, M, Fisch, R, Hohenfellner
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[Epidemiology of childhood cancers].
La Revue du praticien, 2007In industrial countries, 1 child out of 500 develops a cancer before the age of 15 years, and before the age of 6 years for almost half of them. In France, incidence rates were stable over the 15 last years with around 1500 cases each year. A very small fraction of cases is attributable to known risk factors, including heritable cancers or cancers in ...
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