Results 141 to 150 of about 122,293 (305)

Mediating Role of Self-Compassion and Psychological Resilience in the Relationship between Childhood Trauma and Psychosomatic Symptoms in a Non-Clinical Adult Sample

Psikiyatride Güncel Yaklaşımlar
Objective: This study investigates the mediating effects of self-compassion and psychological resilience on the association between childhood trauma and psychosomatic symptoms in a non-clinical adult population.
Kahraman Güler, Simay Ahi
doaj   +1 more source

Childhood maltreatment in adult offspring of Portuguese war veterans with and without PTSD.

, 2014
BACKGROUND: The colonial war that Portugal was involved in between 1961 and 1974 had a significant impact on veterans and their families. However, it is unclear what the consequences of this war are, in particular with regard to levels of childhood ...
Trauma and Grief, Sales, L., Cardoso, R. M., Kleber, Rolf, Leerstoel Kleber, Dos Santos Dias, Aida   +5 more
core   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Personalized Network‐Guided Neuromodulation Enhances Human Working Memory

Advanced Science, EarlyView.
A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan, Hongming Li, Camille Blaine, Julie Grier, Ethan Hammett, Almaris Figueroa‐Gonzalez, Sarai Garcia, Romain Duprat, Justin Reber, Joseph Deluisi, Christos Davatzikos, Theodore D. Satterthwaite, Yong Fan, Desmond J. Oathes   +13 more
wiley   +1 more source

Integration of sexual trauma in a religious narrative: transformation, resolution and growth among contemplative nuns

, 2013
The psychological consequences of sexual abuse are generally serious and enduring, particularly when the perpetrator is known and trusted by the survivor.
Littlewood, R, Durà-Vilà, G, Leavey, G
core  

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

Childhood trauma and cognitive function in first-episode affective and non-affective psychosis

, 2011
Background - A history of childhood trauma is reportedly more prevalent in people suffering from psychosis than in the general population. Childhood trauma has also been linked to cognitive abnormalities in adulthood, and cognitive abnormalities, in turn,
Zanelli, J., Paola Dazzan, Fisher, Helen L; id_orcid, Pariante, C.M., Morgan, Kevin, Morgan, K.D., Aas, M., Jolanta Zanelli, Jones, P.B., Aas, Monica, Dazzan, Paola; id_orcid, Reichenberg, Abraham, Murray, R.M., Murray, Robin M, Pariante, Carmine M; id_orcid, Peter B. Jones, Helen L. Fisher, Robin M. Murray, Fisher, H.L., Fearon, Paul, Jones, Peter B, Monica Aas, Craig Morgan, Reichenberg, A., Morgan, Craig, Abraham Reichenberg, Paul Fearon, Morgan, C., Kevin Morgan, Zanelli, Jolanta, Fearon, P., Dazzan, P., Carmine M. Pariante   +32 more
core   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Sample representation in a psychological treatment study after single event paediatric trauma

, 2013
Children and their families who attended an emergency department following a single traumatic incident and who agreed to participate in a psychological treatment study (N = 211) were compared with nonparticipants (N = 2333) on several measures of trauma ...
Drummond, P.D., Kemp, M.
core  

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source