Results 61 to 70 of about 385,269 (340)

Children's rights : how to promote a rights based approach in residential child care [PDF]

, 2006
This paper promotes the use of children's rights in residential childcare. The 4 key principles of the UNCRC are used as tool to safeguard decision-making in Residential ChildCare.
Vrouwenfelder, Evelyn
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Empowering and Promoting Children’s Rights by Implementing Skills Labs Using Engaging Learning Activities

Societies
Despite the efforts to advance children’s rights’ protection, many children’s rights are still not respected in many places. This makes it more necessary than ever to raise the awareness of children’s rights and prepare new generations of students to ...
Charikleia Pitsou, Ioannis G. Katsantonis, Argyrios Katsantonis, Georgios S. Gorozidis   +3 more
doaj   +1 more source

Allt eller inget? Barns rättigheter i lärarutbildning

Utbildning & Demokrati, 2020
In 2020, the United Nations Convention on the Rights of the Child (UNCRC) is incorporated into Swedish law. In the proposals for new legislation, capacity building was emphasized to generally develop knowledge about children’s rights among professionals ...
Åsa Olsson, Helene Elvstrand, Nina Thelander   +1 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Child Support Right In The Human Rights Perspective

SASI
Introduction: The provision of Article 28 B paragraph (2) and Article 28 D paragraph (1) of the 1945 Constitution of the Republic of Indonesia can be stated as the philosophical basis for children's rights on viability, growth, and development; and the ...
Arief Syahrul Alam, Muhamad Chaidar, Anisah Che Ngah   +2 more
doaj   +1 more source

MODERASI DALAM MEMAKNAI HAK-HAK ANAK

Moderatio, 2022
This paper discusses the concept of moderation in addressing children's rights in terms of family, environment and society. This paper uses a descriptive qualitative research method that is literary in nature.
Siti Nurjanah
doaj  

Peran Pemerintah Daerah untuk Mewujudkan Kota Layak Anak di Indonesia [PDF]

, 2018
The main problems in this research were, first, how is the participation of local governments in realizing children-friendly city/district (KLA) in Indonesia.
Roza, D. (Darmini), S, L. A. (Laurensius)   +1 more
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Caregivers' views on the risk factors impeding implementation of provision rights in children's homes in Harare, Zimbabwe

Social Sciences and Humanities Open
This article focuses on caregivers' views on the risk factors impeding the implementation of children's provision rights in the early childhood development phase in seven children's homes in Harare, Zimbabwe.
Blessing Tendai Baloyi, Jace Pillay, Lucia Munongi   +2 more
doaj   +1 more source