Results 61 to 70 of about 384,128 (291)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Children’s Right to Participate in Ghana: Insights from Parents and Government Officials

SAGE Open
Since the ratification of the Convention on the Rights of the Child (CRC), awareness of children’s inherent value and their right to participate in decision-making processes affecting them has grown significantly.
Frank Kyei-Arthur, Sylvester Kyei-Gyamfi, Evans Sakyi Boadu, Edmund Amarkwei Folley, Ada Adoley Allotey, Theophilus Kwabena Abutima, Henry Afrifa, Bright Appiah   +7 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Empowering and Promoting Children’s Rights by Implementing Skills Labs Using Engaging Learning Activities

Societies
Despite the efforts to advance children’s rights’ protection, many children’s rights are still not respected in many places. This makes it more necessary than ever to raise the awareness of children’s rights and prepare new generations of students to ...
Charikleia Pitsou, Ioannis G. Katsantonis, Argyrios Katsantonis, Georgios S. Gorozidis   +3 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Child Support Right In The Human Rights Perspective

SASI
Introduction: The provision of Article 28 B paragraph (2) and Article 28 D paragraph (1) of the 1945 Constitution of the Republic of Indonesia can be stated as the philosophical basis for children's rights on viability, growth, and development; and the ...
Arief Syahrul Alam, Muhamad Chaidar, Anisah Che Ngah   +2 more
doaj   +1 more source

A World Without Violence Against Children: Children and Young People's Voices and Recommendations for the Post 2015 Agenda [PDF]

, 2014
Preventing and responding to violence and exploitation is essential to ensuring children's rights to survival, development, participation and wellbeing.

core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Towards the Amplification of Children’s Rights within Olympic Discourses

Eracle
The intersection of Mega-Sport Events (MSEs) and human rights has given rise to considerable academic commentary over the last number of years. However, within this literature, the treatment of, and engagement with, children’s rights law, has been ...
Seamus Byrne
doaj   +3 more sources