Results 251 to 260 of about 10,185,945 (317)

Piperazine‐Functionalized Nanoparticles Enable Oral Insulin Delivery in Obese Mice

Advanced Science, EarlyView.
ABSTRACT Biologics have gained prominence as a rapidly advancing therapeutic modality for a diverse spectrum of medical conditions. Nonetheless, they are predominantly administered parenterally due to poor absorption through the gastrointestinal tract. Additionally, repeated injections of biologics such as insulin cause injection pain, leading to dose ...
Yuxue Cao, Xiaofan Jiang, Md Moniruzzaman, Alexandra Mueller, Taskeen Iqbal Janjua, Nisha Tyagi, Zhi Qu, Kuan Yau Wong, Yuran Feng, Aayushi Ghodasara, Ekaterina Strounina, Benjamin P. Ross, Tushar Kumeria, Sumaira Z. Hasnain, Amirali Popat   +14 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Fruit and Vegetable Parenting Practices in Preschoolers: Initial Examination and Cultural Equivalency of a New Measure. [PDF]

Nutrients
Shriver LH, Buehler C.
europepmc   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Interventional treatment of iliac intraosseous arteriovenous malformation: a case description. [PDF]

Quant Imaging Med Surg
Wu Z, Liu Z.
europepmc   +1 more source

The Classroom as Salon: A Collaborative Project on Daniel Defoe’s Robinson Crusoe

Digital Defoe: Studies in Defoe & His Contemporaries, 2013
Suzan Alteri
doaj  

Salpingitis in Non-Sexually Active Girls: Clinical Spectrum and Diagnostic Clues from a Pediatric Cohort. [PDF]

Children (Basel)
Cerutti M, Verzieri M, Gamalero L, Bencini E, Brizzi I, Varriale G, Stagi S, Giani T.   +7 more
europepmc   +1 more source

Problematic media use and callous-unemotional behaviors in early childhood: the roles of emotion regulation and parental mediation. [PDF]

BMC Psychol
Tan R, Hu K, Cai L, Huang P.
europepmc   +1 more source

Parental mediation of smart device use and its impact on language development in early childhood. [PDF]

Sci Rep
Alkouri Z, Aldhafeeri FJ.
europepmc   +1 more source