Results 261 to 270 of about 8,464,968 (354)

Risky outdoor play in the early years: how are parental and practitioner perceptions of danger and benefits associated with young children's outdoor play experiences? [PDF]

Int J Play
McCrorie P, Johnstone A, Nicholls N, Keime M, Jidovtseff B, Martin A.   +5 more
europepmc   +1 more source

DNA Sequential Logic Circuits for Reversible Counters and Dynamic Biomolecular Sensing

Advanced Science, EarlyView.
In this work, a DNA sequential logic circuit is constructed that combines reusability and autonomy for the first time, including SR (Set‐Reset)‐latches composed of NOR gates, SR‐latches composed of NAND gates, and D (Data)‐latches. After fully utilizing the characteristics of each latch, to counter, toxin and miRNA detection and intracellular dynamic ...
Tianci Xie, Changjiang Li, Minghao Hu, Xingyu Zhong, Junbin Xiao, Zhen Zhang, Ze Wang, Tongbo Wu   +7 more
wiley   +1 more source

Peripheral quantitative computed tomography and blood biomarkers in children with spinal cord disorders. [PDF]

Spinal Cord Ser Cases
Ellis J, Galea MP, Scheinberg A, Simm P.
europepmc   +1 more source

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

Advanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu, Nan Li, Yi‐Wen Lv, Wen‐Miao Yang, Zhi‐Yun Yu, Yi‐Min Zhang, Yu Guo, Xiao‐Yin Chen   +7 more
wiley   +1 more source

Clinical and genetic characterization of Lenz-Majewski syndrome with a PTDSS1 variant: a case report and literature review. [PDF]

Front Pediatr
Zhang Y, Wu Y, Yan L, Zhang Y, Li H, He Y.   +5 more
europepmc   +1 more source

Engineering Decavalent, Sperm‐Binding Laminin‐IgG Hybrid Antibodies for Potent Non‐Hormonal Contraception

Advanced Science, EarlyView.
This study investigates a highly multivalent mAb platform fusing Laminin‐511 heterotrimerization domains with Fabs and IgG1‐Fc as a non‐hormonal contraceptive. The most potent molecule ‘LamH10’, possessing 10 Fabs, rapidly achieved >99% reduction in progressively motile sperm at just 33µg per dose in sheep, making the laminin‐IgG hybrid platform the ...
Alison Schaefer, Keiichiro Kushiro, Bhawana Shrestha, Yong Zhu, Alysha Panjwani, Lauren Dawson, Haley Flowers, Kathleen L. Vincent, Samuel K. Lai   +8 more
wiley   +1 more source

Pediatric Pharmacy Association 2025 KIDs List of Key Potentially Inappropriate Drugs in Pediatrics. [PDF]

J Pediatr Pharmacol Ther
McPherson C, Meyers RS, Thackray J, Stutzman DL, Mills KP, Said SJ, Patel K, Hellinga RC, Potts AL, Lubsch L, Matson KL, Hoff DS.   +11 more
europepmc   +1 more source

Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome

Advanced Science, EarlyView.
Shear‐activated nanoparticles carrying nitroglycerin selectively target high‐shear stress collateral vessels during ischaemic stroke, enhancing blood flow to at‐risk brain without systemic side effects. This novel approach significantly improves outcomes in animal models, outperforming conventional nitroglycerin delivery.
Magdalena Litman, Sara Azarpeykan, Rebecca J Hood, Kristy Martin, Debbie Pepperall, Daniel Omileke, Fern Williams, Oktay Uzun, Deen Bhatta, Yuen K Yong, Alex Chan, Nicholas Hough, Sarah Johnson, Pablo Garcia Bermejo, Ferdinand Miteff, Carlos Garcia Esperon, Yvonne Couch, Alastair M Buchan, Neil J Spratt, Netanel Korin, Donald E Ingber, Daniel J Beard   +21 more
wiley   +1 more source