Results 81 to 90 of about 925,473 (318)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Becoming curious about cats: A collaborative writing project [PDF]

, 2010
Students’ interests and achievement in writing are often debated and located in theoretical and pedagogical arguments. These issues can polarise understandings of effective teaching practice.
Amoore, Liz, Dix, Stephanie Margaret
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

A study on the literary elements of children’s literature classics and their influence on reading experience based on principal component analysis [PDF]

, 2023
Yu Fu
openalex   +1 more source

Children’s buying behaviour in China: A study of their information sources [PDF]

, 2008
Purpose Reports an empirical study on children’s buying behaviour in China with a special focus on their information sources. Design /Methodology The key literature on consumer socialisation of children is reviewed.
Fan, Y, Li, Y
core  

Holding and restraining children for clinical procedures within an acute care setting: an ethical consideration of the evidence [PDF]

, 2014
This critical reflection on the ethical concerns of current practice is underpinned by a systematic synthesis of current evidence focusing on why and how children are held or restrained for clinical procedures within acute care and the experiences of ...
Alderson, Alexander, Bigwood, Bradlyn, Brenner, Bricher, Bricher, Carnevale, Carter, Cavender, Chuang, Collier, Crellin, Dahlquist, Dashti, Delaney, Demir, Department of Health, Dixon-Woods, Ersig, Fanurik, Freeman, Gil, Graham, Hart, Homer, Ives, Jaaniste, Jameton, Kain, Kleiber, Lahman, Lansdown, Larkin, Lewis, Lloyd, Lundqvist, Lundqvist, Mathew, Matsumori, McGrath, McGrath, Naber, National Institute of Clinical Excellence, Noddings, Ofoegbu, Piira, Poikkeus, Robinson, Rodney, Royal College of Nursing, Royal College of Nursing, Runeson, Runeson, Selekman, Smith, Smith, Snyder, Sparks, Stacey, Stewart, Swallow, UN General Assembly   +62 more
core   +1 more source

PENERJEMAHAN NAMA TOKOH KARYA SASTRA ANAK KE DALAM BAHASA INDONESIA <em>(THE TRANSLATION OF CHARACTER’S NAME IN CHILDREN’S LITERATURE INTO INDONESIAN)</em>

Jalabahasa, 2018
Makalah ini mendiskusikan penerjemahan nama dalam karya sastra anak. Keunikan penerjemahan untuk anak-anak adalah penerjemah fokus pada pembaca sasaran. Objek penelitian pada tulisan ini adalah nama karakter dalam cerita Walt Disney. Teknik penerjemahan nama yang digunakan adalah peminjaman murni, peminjaman alamiah, harfi ah, dan adaptasi.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

De tres en tres : carreras en la literatura infantil y juvenil [PDF]

, 2013
1 archivo PDF (9 páginas)El relato de una vida entera influenciada por la pasión a la lectura y cómo la autora, en su desempeño profesional fue capaz de traslapar su bagaje cultural para impulsar importantes proyectos dentro de la Literatura infantil y ...
Roberts, Anne, Sánchez Valencia, Alejandra, traductora   +1 more
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source