Results 51 to 60 of about 68,115 (234)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Challenges in Implementing Sharia-Based Education: Balancing Regional Autonomy and Children’s Rights in Aceh

Khazanah Hukum
This study analyzes the implementation of Sharia-based education in Aceh through the perspective of regional autonomy and children's rights.  This multidisciplinary study reveals the tension between Aceh's education policies (Law No.
Mukhlis Mukhlis, Muhammad Iqbal, Maya Safitri, Hasniyati Hasniyati   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Child-Right-ing: Going Beyond Innocence to Realize the Rights of Undocumented Migrant Children through Struggles for the Rights of All Children

Nordic Journal of Migration Research
Children’s rights are a blessing and a curse for undocumented migrant children. They are one of few available resources in migrant struggles, but at the same time they are also extensively mobilized to govern children’s mobility. In this article, I first
Jacob Lind
doaj   +1 more source

RIGHT AND WRONG FROM THE PERSPECTIVE OF 8- AND 12-YEAR-OLD CHILDREN: AN EXPLORATORY ANALYSIS

International Journal of Child, Youth & Family Studies, 2018
Understanding rights not only means knowing what is permitted by law and what is not, but also being aware of and knowing one’s own rights as a human being.
Kira Ammann
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

AI, education, and children’s rights

Frontiers in Education
Artificial Intelligence (AI) systems are increasingly being used in education. However, the impact that these AI systems are having on children’s rights is mostly overlooked. This paper aims to further a discussion around that omission.
Wayne Holmes, Wayne Holmes
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Children’s Right to Participate in Ghana: Insights from Parents and Government Officials

SAGE Open
Since the ratification of the Convention on the Rights of the Child (CRC), awareness of children’s inherent value and their right to participate in decision-making processes affecting them has grown significantly.
Frank Kyei-Arthur, Sylvester Kyei-Gyamfi, Evans Sakyi Boadu, Edmund Amarkwei Folley, Ada Adoley Allotey, Theophilus Kwabena Abutima, Henry Afrifa, Bright Appiah   +7 more
doaj   +1 more source