Results 61 to 70 of about 68,533 (233)
Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas +3 more
wiley +1 more source
Children’s Wellbeing and Children’s Rights—A Nordic Perspective
Social SciencesChildren’s rights and wellbeing have increasingly attracted attention both politically and in the scholarly field [...]
Sarah Alminde, Hanne Warming
doaj +1 more source
A Comparative Reading of Children's Economic Rights in the Legal Systems of Iran, the United States, and International Instruments [PDF]
پژوهشنامه حقوق اسلامیContext & Objective: Children's economic rights are a critical dimension of human rights, requiring focused legal protection across various jurisdictions and international frameworks. This article explores and compares the legislative approaches toward
Mahdi Mollaei
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Social Sciences and Humanities OpenThis article focuses on caregivers' views on the risk factors impeding the implementation of children's provision rights in the early childhood development phase in seven children's homes in Harare, Zimbabwe.
Blessing Tendai Baloyi +2 more
doaj +1 more source
Towards the Amplification of Children’s Rights within Olympic Discourses
EracleThe intersection of Mega-Sport Events (MSEs) and human rights has given rise to considerable academic commentary over the last number of years. However, within this literature, the treatment of, and engagement with, children’s rights law, has been ...
Seamus Byrne
doaj +3 more sources
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Вісник Харківського національного університету імені В. Н. Каразіна Серія: «Право»Introduction. The article examines the peculiarities of the formation and functioning of the international legal mechanism for protecting children’s environmental rights at the international universal level within the framework of the United Nations. The
Ihor Voievodin
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source