Results 261 to 270 of about 9,035,003 (377)

HNF3α Targets Nckap1l and Promotes Renal Fibrosis Following Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
Hepatocyte Nuclear Factor 3 alpha (HNF3α) is significantly upregulated in renal tubular epithelial cells of CKD patients and fibrotic mice. Deletion of HNF3α mitigates IRI‐induced renal fibrosis, while overexpression worsens it. HNF3α directly regulates NCK‐associated protein 1‐like (Nckap1l), whose overexpression exacerbates fibrosis.
Ling Hou   +7 more
wiley   +1 more source

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation

open access: yesAdvanced Science, EarlyView.
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao   +11 more
wiley   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

open access: yesAdvanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan   +16 more
wiley   +1 more source

Genome‐Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat

open access: yesAdvanced Science, EarlyView.
In this study, variation and genetic basis of ionome among Tartary buckwheat population are investigated, illuminating their significance in the domestication and diversification of Tartary buckwheat. And three genes (FtACA13 for Na content, FtYPQ1 for Zn content, FtNHX2 for As content) are identified with the dominant haplotypes and functional ...
Zhirong Wang   +18 more
wiley   +1 more source

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