Results 91 to 100 of about 274,430 (199)

Treatment response and remission in a double-blind, randomized, head-to-head study of lisdexamfetamine dimesylate and atomoxetine in children and adolescents with attention-deficit hyperactivity disorder [PDF]

, 2014
A secondary objective of this head-to-head study of lisdexamfetamine dimesylate (LDX) and atomoxetine (ATX) was to assess treatment response rates in children and adolescents with attention-deficit hyperactivity disorder (ADHD) and an inadequate response
Esther Cardo, Hodgkins, P, Dittmann, RW, Caballero, B, Beatriz Caballero, Cardo, E, Adeyi, Ben, Civil, R, Ben Adeyi, Anderson, CS, Civil, Richard, Colleen S. Anderson, Hodgkins, Paul, Cardo-Jalon, Esther, Coghill, DR, Nagy, Peter, Cardo, Esther, Richard Civil, David R. Coghill, Anderson, Colleen S., Adeyi, B, Coghill, David R., Dittmann, Ralf W., Peter Nagy, Nagy, P, Caballero, Beatriz, Ralf W. Dittmann, Paul Hodgkins   +27 more
core   +1 more source

TREM2 Downregulation Disrupts Microglial Function and Synaptic Pruning Through RA/RARα Signaling: Mechanisms Underlying Autism‐Like Behaviors

Pediatric Discovery
Autism spectrum disorder (ASD) involves neuroimmune dysregulation and synaptic pruning defects. This study aimed to investigate the role of triggering receptor expressed on myeloid cells 2 (TREM2) in ASD pathogenesis and its link to retinoic acid (RA ...
Min Lu, Kexin Bai, Yali Bai, Yuan Miao, Tingjiao Zhao, Yi Yang, Jie Chen, Ting Yang, Tingyu Li, Hua Wei   +9 more
doaj   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Hostile behaviours in children and adolescents: Sociodemographic and parental variables [PDF]

, 2016
Background: Hostile behaviour in children and adolescents is a current and very relevant problem due to individual, social and economic harm it produces.
Nelas, Paula, Cruz, Carla, Amaral, Odete, Chaves, Cláudia, Campos, Sofia, Antunes, Anabela, Almeida, Mariline   +6 more
core   +1 more source

Modifiable factors influencing attention performance in healthy children: insights from a comprehensive school nutrition study

BMC Public Health
Background There is inconclusive evidence for the effects of various leisure activities on attention performance in children. The literature reports inconsistent associations between activities such as physical activities or media use.
Peggy Ober, Tanja Poulain, Christof Meigen, Ulrike Spielau, Carolin Sobek, Wieland Kiess, Ulrike Igel, Tobias Lipek, Mandy Vogel   +8 more
doaj   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Kick Scooter Injuries in Children and Adolescents : Minor Fractures and Bruise [PDF]

, 2018
Background: Kick scooters are popular among children in both transportation and recreational activities. The aim of this retrospective study was to assess the incidence of and injury patterns associated with kick scooter accidents in school-aged children
Kallio, P., J. H. Unkuri, S. Kosola, Unkuri, J. H., Kosola, S., Salminen, P., P. Kallio, P. Salminen   +7 more
core   +1 more source

Specifics of dyadic coping in couples facing vision loss: a qualitative analysis

Cogent Psychology
Objective Vision loss is a widespread and debilitating chronic condition that can be stressful for patients and partners, potentially impairing couples’ psychological functioning.
Katharina Weitkamp, Christina J. Breitenstein, Rhea Sarah Gesù, Guy Bodenmann   +3 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source