Results 1 to 10 of about 343,614 (120)

The Development of the Evidence-Informed “OI Splint Kit” for Children with Osteogenesis Imperfecta and Their Families

McGill Journal of Medicine, 2022
Background: Children with osteogenesis imperfecta (OI) live in fear of fracturing a bone. As fractures are unpredictable, there is a need for tools and knowledge to immobilize a fracture during emergencies.
Sofia Addab, Stephanie Thierry, Marie-Elaine Lafrance, Sunny Jeong, Jennifer Brown, Carter Brown, Sylvie-Anne Plourde, Angela Gugliotti, Kelly Thorstad, Reggie Hamdy, Frank Rauch, Argerie Tsimicalis   +11 more
doaj   +1 more source

The Direct and Indirect Financial Costs Sustained by Parents of Children with Osteogenesis Imperfecta

McGill Journal of Medicine, 2022
Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a rare genetic condition characterized by increased bone fragility. The financial costs of caring for a child with a rare condition can be a significantsource of stress for families ...
Aimee Castro, Marilyn Morand, Frank Rauch, Argerie Tsimicalis   +3 more
doaj   +1 more source

Variable expressivity in a family with an aggrecanopathy

Molecular Genetics & Genomic Medicine, 2022
Background Osteochondritis dissecans is a condition wherein there is a subchondral bone lesion that causes pain, inflammation, and cartilage damage. Dominant Familial Osteochondritis Dissecans is a rare and severe form of osteochondritis dissecans (OCD).
Antoine Denis, Sami Chergui, Shuaa Basalom, Philippe M. Campeau, Chantal Janelle, Thierry Pauyo   +5 more
doaj   +1 more source

Bone health in spacefaring rodents and primates: systematic review and meta-analysis

npj Microgravity, 2021
Animals in space exploration studies serve both as a model for human physiology and as a means to understand the physiological effects of microgravity.
Jingyan Fu, Matthew Goldsmith, Sequoia D. Crooks, Sean F. Condon, Martin Morris, Svetlana V. Komarova   +5 more
doaj   +1 more source

A roadmap to surgery in osteogenesis imperfecta: results of an international collaboration of patient organizations and interdisciplinary care teams

Acta Orthopaedica, 2021
Background and purpose — Involvement of patient organizations is steadily increasing in guidelines for treatment of various diseases and conditions for better care from the patient’s viewpoint and better comparability of outcomes.
Ralph J Sakkers, Kathleen Montpetit, Argerie Tsimicalis, Thomas Wirth, Marjolein Verhoef, Reginald Hamdy, Jean A Ouellet, Rene M Castelein, Chantal Damas, Guus J Janus, Wouter H Nijhuis, Leonardo Panzeri, Simona Paveri, Dagmar Mekking, Kelly Thorstad, Richard W Kruse   +15 more
doaj   +1 more source

Validation of the Critical-Care Pain Observation Tool (CPOT) in pediatric patients undergoing orthopedic surgery

Canadian Journal of Pain, 2023
Background Postoperative pain cannot be measured accurately among many children with intellectual and developmental disabilities, resulting in underrecognition or delay in recognition of pain.
Mandy M. J. Li, Don Daniel Ocay, Cynthia L. Larche, Kelsey Vickers, Neil Saran, Jean A. Ouellet, Céline Gélinas, Catherine E. Ferland   +7 more
doaj   +1 more source

Epidemiology, aetiology, interventions and genomics in children with arthrogryposis multiplex congenita: protocol for a multisite registry

BMJ Open, 2022
Introduction Arthrogryposis multiplex congenita (AMC) is an umbrella term including hundreds of conditions with the common clinical manifestation of multiple congenital contractures.
Philip Giampietro, Judith Hall, Frank Rauch, Noémi Dahan-Oliel, Michelle James, Tanya Bedard, Vasiliki Betty Darsaklis, Harold van Bosse, Ghalib Bardai, Ellen Raney, Krister Freese, Lauren Hyer, Jonathan Pellett, Reggie Charles Hamdy, Haluk Altiok   +14 more
doaj   +1 more source

PARENTS AND ATHLETES PERCEIVE PAIN AND PEER RELATIONSHIPS DIFFERENTLY: EARLY RESULTS OF A PROMIS DYAD STUDY

Orthopaedic Journal of Sports Medicine, 2021
Introduction: Parents/caregivers are a crucial part of young athletes’ support systems, as their beliefs can have a profound effect on the athletes’ treatment and recovery.
Corinna C Franklin MD, Kevin Moran BS, ,   +3 more
doaj   +1 more source

Uncovering a multitude of human glucocorticoid receptor variants: an expansive survey of a single gene

BMC Genetics, 2019
Background Glucocorticoids are commonly used in the clinical setting for their potent anti-inflammatory effects; however, significant variations in response to treatment have been demonstrated.
Stacey M. Leventhal, Debora Lim, Tajia L. Green, Anna E. Cantrell, Kiho Cho, David G. Greenhalgh   +5 more
doaj   +1 more source

Chameleon project: a children’s end-of-life care quality improvement project

BMJ Open Quality, 2021
In response to there being no specialist paediatric palliative care (PPC) team in a region of England, we undertook a 12-month quality improvement project (funded by National Health Service England’s Marginal Rate Emergency Threshold and Readmission fund)
Joseph C Manning, Hayley Griffin, Nicola Kelly, Sarah Haynes, Jennifer Turnbull, Helena Clements, Kerry Webb, Toni Wolff, Caroline Dorsett, Alexander Connolly, Anjum Deorukhkar, Anjana Chhaochharia   +11 more
doaj   +1 more source