Results 11 to 20 of about 338,204 (164)

Uncovering a multitude of human glucocorticoid receptor variants: an expansive survey of a single gene

BMC Genetics, 2019
Background Glucocorticoids are commonly used in the clinical setting for their potent anti-inflammatory effects; however, significant variations in response to treatment have been demonstrated.
Stacey M. Leventhal, Debora Lim, Tajia L. Green, Anna E. Cantrell, Kiho Cho, David G. Greenhalgh   +5 more
doaj   +1 more source

Chameleon project: a children’s end-of-life care quality improvement project

BMJ Open Quality, 2021
In response to there being no specialist paediatric palliative care (PPC) team in a region of England, we undertook a 12-month quality improvement project (funded by National Health Service England’s Marginal Rate Emergency Threshold and Readmission fund)
Joseph C Manning, Hayley Griffin, Nicola Kelly, Sarah Haynes, Jennifer Turnbull, Helena Clements, Kerry Webb, Toni Wolff, Caroline Dorsett, Alexander Connolly, Anjum Deorukhkar, Anjana Chhaochharia   +11 more
doaj   +1 more source

Children’s health-related experiences in India: A scoping review

McGill Journal of Medicine, 2023
Background & Objectives: The perspectives of children have becoming increasingly emphasized in healthcare research and practice in order to facilitate children’s inclusion, participation, and decision-making in matters related to their health. In India,
Yi Wen Wang, Justine Behan, Sunny Jeong, Ramandeep Singh Arora, Franco Carnevale, Argerie Tsimicalis   +5 more
doaj   +1 more source

Opioid-free recovery after laparoscopic-assisted redo pull-through and loop ileostomy via sacral and thoracic erector spinae plane blocks

Journal of Pediatric Surgery Case Reports, 2021
Multi-modal analgesia with a reduction in perioperative opioid use has been a goal for many institutions due to the ongoing opioid epidemic. A reduction in opioid use can also limit undesirable side effects such as nausea, respiratory depression, and ...
Adam P. Chao, Sampaguita Tafoya, Payam Saadai, Shinjiro Hirose   +3 more
doaj   +1 more source

Effects of intermittent T-cell cluster disaggregation on proliferative capacity and checkpoint marker expression

Autoimmunity, 2019
Background/aim: T-cell immunotherapies are rapidly gaining grounds in clinical success. Presently, there is first-to-market knowledge on the translation of research scale methods to clinical and commercial scales.
Matthew Li, Ling-Yee Chin, Sykuri Shukor, Alfred G. Tamayo, Marcela V. Maus, Biju Parekkadan   +5 more
doaj   +1 more source

A Multicenter Study of Intramedullary Rodding in Osteogenesis Imperfecta

JBJS Open Access, 2020
Background:. Osteogenesis imperfecta (OI), a heritable connective tissue disorder with wide clinical variability, predisposes to recurrent fractures and bone deformity.
Mercedes Rodriguez Celin, MD, Karen M. Kruger, PhD, Angela Caudill, PT, MPT, Sandesh C.S. Nagamani, MD, Brittle Bone Disorders Consortium (BBDC), Linked Clinical Research Centers (LCRC), Gerald F. Harris, PhD, PE, Peter A. Smith, MD   +7 more
doaj   +1 more source

Same but different? A thematic analysis on adalimumab biosimilar switching among patients with juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal, 2019
Background Biologic medications have dramatically enhanced the treatment of many chronic paediatric inflammatory conditions. Their high cost is a factor that prohibits their broader use.
William D. Renton, Helen Leveret, Catherine Guly, Heather Smee, Jamie Leveret, Athimalaipet V. Ramanan   +5 more
doaj   +1 more source

Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways

Nature Communications, 2020
In the central nervous system, the maturation of glial cells is temporally and functionally coupled with that of the vascular network during postnatal development.
Sheng Zhang, Bokyung Kim, Xiaoqing Zhu, Xuehong Gui, Yan Wang, Zhaohui Lan, Preeti Prabhu, Kenneth Fond, Aijun Wang, Fuzheng Guo   +9 more
doaj   +1 more source

VR over Matter

McGill Journal of Medicine
Medical procedures, like IV insertions and pin removals, may cause pain and anxiety in children. While preventable, high rates of procedural pain persist in hospitals.
Stephanie Smith, Sofia Addab, Kelly Thorstad, Reggie Hamdy, Argerie Tsimicalis   +4 more
doaj   +1 more source

Collagen Type I as a Ligand for Receptor-Mediated Signaling

Frontiers in Physics, 2017
Collagens form the fibrous component of the extracellular matrix in all multi-cellular animals. Collagen type I is the most abundant collagen present in skin, tendons, vasculature, as well as the organic portion of the calcified tissue of bone and teeth.
Iris Boraschi-Diaz, Iris Boraschi-Diaz, Jennifer Wang, John S. Mort, Svetlana V. Komarova, Svetlana V. Komarova   +5 more
doaj   +1 more source