Results 141 to 150 of about 2,826,722 (313)
Advanced Materials, EarlyView.A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton +17 more
wiley +1 more source
Inpatient Services for Children [PDF]
Public Health Reports (1896-1970), 1957 openaire +2 more sources
Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis
Advanced Materials, EarlyView.This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar +5 more
wiley +1 more source
Resourceful leadership: how directors of children’s services improve outcomes in schools and early years; summary report [PDF]
, 2011 This targeted report has been published alongside a longer report, "Resourceful leadership: how directors of children’s services improve outcomes for children.
core
Respiratory Signal Processing and Analysis Using Flexible Capacitive Sensor Data
Advanced Materials Technologies, EarlyView.Capacitive pressure sensors based on poly(glycerol sebacate) (PGS) substrates are developed for continuous, non‐invasive respiratory monitoring. Integrated with a signal processing algorithm, they enable accurate tracking of thoracic expansion and retraction.
Bernardo A. Vicente +3 more
wiley +1 more source
Ophthalmic services for children [PDF]
Archives of Disease in Childhood, 1985 openaire +2 more sources
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source
Ophthalmic services for children [PDF]
British Journal of Ophthalmology, 1995 openaire +2 more sources
Integrating services for young children and their families [PDF]
In an effort to improve outcomes for young children and their families, governments in all developed nations are making efforts to integrate services more effectively.
Centre for Community Child Health
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EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer
Advanced Science, EarlyView.This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv +8 more
wiley +1 more source