Results 11 to 20 of about 210,454 (261)
Vestnik RUDN. International Relations, 2022 The evolution of regionalism in Latin America has historically been greatly influenced by changes in governments and their ideological programs. In this article, looking at the courses of the administrations of Jair Bolsonaro in Brazil, Ivan Duque in ...
Viktor L. Jeifets, Kseniya A. Konovalova
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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La formación inicial docente en Chile: Una revisión bibliográfica sobre su implementación y logros
Revista Electrónica Educare, 2022 Introducción. En Chile, durante las últimas décadas se han implementado diversas políticas educativas orientadas a mejorar la formación inicial docente, con el propósito de impactar en la calidad del sistema educativo. Han sido varias las investigaciones
Lady Sthefany Bastías-Bastías +1 more
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AUS, 2006 Descentralización, heterogeneidad, desarticulación, dislocación, son términos que se utiliza hoy para caracterizar una nueva condición cultural. En todos aquellos dominios que informan la saciedad contemporánea, sus ciencias y su arte, un ligero cambio es perceptible a través de la erosión de las ilusiones universalistas de la primera mitad del siglo ...
openaire +2 more sources
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
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Kairós, Revista de Ciencias Económicas, Jurídicas y Administrativas, 2023 Se propone relevar la percepción de los cuidados con el objeto de identificar las dificultades de las familias en las comunas de Chile. Se utiliza como metodología el estudio de opinión: “Percepciones sobre los cuidados en la familia en Chile”.
Alejandra A. Retamal-Retamal +1 more
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FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
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The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
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V JORNADA DE INVESTIGACIÓN 2017 DIVISIÓN DE PEDIATRÍA
ARS Medica, 2017 Pontificia Universidad Católica de Chile, Jueves 30 de Marzo 2017, Aula Magna Manuel José ...
Pontificia Universidad Católica de Chile
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