Results 31 to 40 of about 1,825,271 (304)
Kairós, Revista de Ciencias Económicas, Jurídicas y Administrativas, 2023 Se propone relevar la percepción de los cuidados con el objeto de identificar las dificultades de las familias en las comunas de Chile. Se utiliza como metodología el estudio de opinión: “Percepciones sobre los cuidados en la familia en Chile”.
Alejandra A. Retamal-Retamal +1 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
V JORNADA DE INVESTIGACIÓN 2017 DIVISIÓN DE PEDIATRÍA
ARS Medica, 2017 Pontificia Universidad Católica de Chile, Jueves 30 de Marzo 2017, Aula Magna Manuel José ...
Pontificia Universidad Católica de Chile
doaj +1 more source
Luchoelmis : a new genus of Elmidae (Coleoptera) from Chile and Argentina [PDF]
, 2002 Luchoelmis New Genus is described with four new species: aequalis, magallanensis, and penai from Chile and cekalovici from Argentina and Chile. Luchoelmis penai is designated as the type species of the genus.
Spangler, P. J., Staines, Charles L.
core
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
Revista de estudios teóricos y epistemológicos en política educativa, 2020 En las últimas décadas, la aplicación de políticas neoliberales en los sistemas escolares se convirtió en una tendencia mundial. Su éxito se explica, en parte, por la difusión de un nuevo imaginario, cuyos valores están fuertemente vinculados a las ...
Camila Pérez Navarro +1 more
doaj +1 more source
Relationship between genetic diversity of Chenopodium quinoa and the dynamics of its seed exchanges in Chile [PDF]
, 2011 Quinoa cultivation in Chile presents an ancient and active complex of geographic, climatic, social and cultural interactions that has determined its current biodiversity in the three main growing zones (north, centre and south).
Bazile, Didier +3 more
core
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source