Results 201 to 210 of about 6,753,342 (308)

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

A tale of two lineages: comparative biogeography across the Southern Cone of two South American Carex (Cyperaceae) groups. [PDF]

Ann Bot
Morales-Alonso A, Muñoz-Schüler P, Villaverde T, Jiménez-Mejías P.   +3 more
europepmc   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Increased Temperatures Promote Fruit Enlargement Through Cellular and Transcriptomic Changes in Raspberries (<i>Rubus idaeus</i> L.) cv. Heritage. [PDF]

Plants (Basel)
Hernández-Urrieta J, García S, Estait L, Aguilar F, O'Brien JA, Jerez A, Contreras C.   +6 more
europepmc   +1 more source

Polydopamine‐Wool Textiles for Sustainable Interfacial Solar Vapor Generation

Advanced Science, EarlyView.
A natural wool textile engineered for high solar absorbance and a fast‐wicking structure serves as a highly efficient, single‐layer system for interfacial solar vapor generation (ISVG). This integrated evaporator seamlessly couples rapid water transport with continuous evaporation. Ultimately, this sustainable photothermal design offers a scalable, eco‐
Kyuin Park, Jintong Gao, Hansadi Jayamaha, Yipu Wang, Mia Bressler, Lenan Zhang, Larissa M. Shepherd   +6 more
wiley   +1 more source

Muscle Strength as a Key Independent Predictor of Arterial Stiffness and Metabolic Syndrome in Aging Mexicans: Unveiling the Sarcopenic Obesity Paradox. [PDF]

J Clin Med
Garcia-Carrillo E, Pezoa-Fuentes P, Guzmán-Muñoz E, Concha-Cisternas Y, Montalva-Valenzuela F, Olivares-Arancibia J, González-Aroca J, Cortés-Roco G, Yáñez-Sepúlveda R.   +8 more
europepmc   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Presence of <i>Dirofilaria immitis</i> in domestic cats and dogs in Chile: Assessment of monthly infection risk as a preventive tool. [PDF]

Curr Res Parasitol Vector Borne Dis
Morchón R, Gil-Abad A, Infante González-Mohino E, Collado-Cuadrado M, Balmori-de la Puente A, Castro-Seriche S, Montoya-Alonso JA, Carretón E, Rodríguez-Escolar I.   +8 more
europepmc   +1 more source

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

[The HEARTS initiative: Experience with community cardiovascular health champions in a municipality in ChileIniciativa HEARTS: experiência com promotores comunitários de saúde cardiovascular em um município chileno]. [PDF]

Rev Panam Salud Publica
Vega Gual C, Brun Mautino G, Norambuena Perea D, Véliz Lobos R, Zapata Neculhueque X, Flores González E, Neira Ojeda C, Rivera Medina M.   +7 more
europepmc   +1 more source