Results 221 to 230 of about 6,753,342 (308)

Evolution of Multitarget Strategies for Alzheimer's Disease: From Cholinergic Inhibition to Network-Oriented Therapeutic Design (2006-2025). [PDF]

Pharmaceuticals (Basel)
Mella J, Vega-Muñoz A, Soto M, Moraga D, Campanini-Salinas J, Sandoval-Obando E, Contreras-Barraza N, Salazar-Sepúlveda G, Salas-Guzmán N, Carabantes-Silva R, Mellado M.   +10 more
europepmc   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Banco central de Chile. Memoria anual.

Banco central de Chile
core  

Resistance to anti-TB drugs: evaluation of universal resistance surveillance implementation in Chile. [PDF]

IJTLD Open
Barra GN, Oyarte M, Ivani KK, Briceño ÁD, Espinoza IM, Calderón TL, Juica MM, Bordón AS, Oviedo JF, Muñoz FA.   +9 more
europepmc   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Banco central de Chile. Annual report.

Banco central de Chile
core  

The Evolution of Phytochemical and Medicinal Plant Research in Chile: Status, Opportunities, and Challenges. [PDF]

Plants (Basel)
Fuentes-Barros G, Castro-Saavedra S, Montalva N, Vega-Muñoz A, Mella J, Díaz-Valdés A, Zoppi C, Avanco AC, Mellado M, Echeverría J.   +9 more
europepmc   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Institution Building in a World of Free and Volatile Capital Flows: A Case Study of Chile [PDF]

Central Bank of Chile Working Group for the 11th APEC Finance Ministers’ Meeting
core  

Recovery of Seed Quality and Germination Success Following Severe Wildfires in <i>Araucaria araucana</i> Forests of the Southern Andes. [PDF]

Ecol Evol
Fuentes-Ramírez A, Díaz-Mons B, Vargas-Gaete R, Herrera H, Almonacid L.   +4 more
europepmc   +1 more source