Results 81 to 90 of about 58,451 (265)

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Diversidad de micromamíferos en tres ambientes de la Reserva Nacional Lago Peñuelas, Región de Valparaíso, Chile Diversity of small mammals in three environments of the National Reserve Lago Peñuelas, Región de Valparaíso, Chile

Gayana, 2010
Los ecosistemas mediterráneos de Chile, los únicos en Sudamérica de los cuatro presentes en el mundo, son considerados áreas prioritarias para la conservación, por su alta concentración de especies endémicas y las aceleradas tasas de destrucción del ...
Andrés Muñoz-Pedreros, Susan Fletcher, José Yáñez, Pamela Sánchez   +3 more
doaj  

A Centralized Auction Mechanism for the Disability and Survivors Insurance in Chile [PDF]

, 2009
As part of the pension reform recently approved in Chile, the government introduced a centralized auction mechanism to provide the Disability and Survivors (D&S) Insurance that covers recent contributors among the more than 8 million participants in the mandatory private pension system.
openaire   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

A time-energy analysis of daytime surface activity in degus, Octodon degus Análisis del uso de tiempo y energía en la actividad superficial diaria en degus, Octodon degus

Revista Chilena de Historia Natural, 2002
We present an analysis of time and energy allocation in a day-active caviomorph rodent, the degu, Octodon degus, in central Chile. We quantified components of surface activity in the field on a daily basis in individual degus near the time of the summer ...
G.J. Kenagy, Rodrigo A. Vásquez, Roberto F. Nespolo, Francisco Bozinovic   +3 more
doaj  

Activismos creativos en la comunidad soviet wave: fantasmas de un futuro soñado

Designio. Investigación en Diseño Gráfico y Estudios de la Imagen
El objetivo de este artículo es estudiar las imágenes del género musical soviet wave a partir de la función estética de la nostalgia como resultado de la ruptura temporal que significó la caída de la ex Unión Soviética y otros desastres aunados, como el ...
Ingrid Sánchez Téllez, Juan Contreras Escobar, Claudio Contreras Escobar   +2 more
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Trayectorias de paternidades homosexuales en Chile

Revista Latinoamericana de Estudios de Familia
this article exposes the trajectory regarding the process of configuration of homosexual parenthood in men who were fathers in previous heterosexual relationships.
Gonzalo Soto-Guzmán, Javier Ruiz-Ríos, Mladen Matulic-Cvitanic   +2 more
doaj   +1 more source

Tornado Seasonality in Central‐Southern Chile

Geophysical Research Letters
AbstractTornado records in Chile show an apparent seasonality with a peak between May and June. We study this seasonality in central‐south and austral Chile by analyzing three indicators of tornado environments: vorticity generation parameter (VGP), storm‐relative helicity (SRH) and mean relative humidity . Annual cycles of VGP, SRH and show favorable
V. Caballero‐Morán, R. Rondanelli
openaire   +2 more sources