Results 91 to 100 of about 58,451 (265)

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Representaciones de las personas mayores en los estudios sobre migraciones, cuidados y envejecimiento

Si Somos Americanos
Este artículo tiene como objetivo ofrecer un panorama general sobre el tratamiento dado a las personas mayores en la literatura sobre migraciones latinoamericanas y caribeñas, el envejecimiento y la organización local/transnacional de los cuidados, desde
Herminia Gonzálvez-Torralbo, Ariany da Silva Villar   +1 more
doaj   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

[Medical specialization in Chile. A centralized vision].

Revista medica de Chile, 2018
Medical graduates face different postgraduate training options, but their priority is to obtain a primary medical specialty, defined as a specialty that does not derive from other. There are different specialty training programs in Chile, which can be dependent or independent of the Ministry of Health.
Diego E, Clouet-Huerta, Bárbara, González, Katherine, Correa   +2 more
openaire   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Holocene distribution of Octodontid rodents in central Chile Distribución holocénica de roedores octodóntidos en Chile central

Revista Chilena de Historia Natural, 2003
We describe the Holocene distribution of the Octodontids Aconaemys fuscus, Octodon bridgesi, O. degus, O. lunatus, O. pacificus and Spalacopus cyanus from Central Chile. We compared ancient and present day ranges.
BÁRBARA SAAVEDRA, JAVIER A SIMONETTI
doaj  

Mitochondrial Carrier SLC25A13 Drives Ferroptosis Resistance and Immune Evasion via a STAT3–IFI6 Circuit in Breast Cancer

Advanced Science, EarlyView.
SLC25A13 is identified as an immunometabolic driver of triple‐negative breast cancer that sustains ferroptosis resistance and immune evasion through a STAT3–IFI6 circuit. Pharmacologic degradation of SLC25A13 restores ferroptosis sensitivity and enhances anti‐PD‐1 efficacy, highlighting a strategy to convert immune‐cold tumors into immunotherapy ...
Yingze Zhu, Yuhan Tang, Yingcui Chen, Zhuoqi Zhang, Yige Lu, Xinyue Wang, Qiyuan Shi, Wenhui Zhao, Hui Pang   +8 more
wiley   +1 more source

ZELUS CERVICALIS STÅL (HEMIPTERA: REDUVIIDAE: HARPACTORINAE), APORTE NEARTICO A LA ENTOMOFAUNA INTRODUCIDA EN CHILE ZELUS CERVICALIS STÅL (HEMIPTERA: REDUVIIDAE: HARPACTORINAE), NEARCTIC APORT TO INTRODUCED CHILEAN ENTOMOFAUNA

Gayana, 2004
Se da a conocer el establecimiento en Chile de Zelus cervicalis Stål, 1872, cuya introducción reciente en el país se asocia al tráfico comercial. Se entrega una breve caracterización, sinonimia, referencias bibliográficas, distribución geográfica ...
Mario Elgueta, Diego L. Carpintero
doaj  

Encarcelamiento femenino en Chile. Los efectos ocultos de la guerra contra las drogas en madres cuidadoras

Justicia
El presente trabajo busca elaborar directrices con perspectiva de género para una nueva política criminal en delitos de drogas, considerando especialmente el impacto que genera el encarcelamiento en las mujeres y sus hijas e hijos.
Silvio Cuneo, María José Fernández
doaj   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source