Results 111 to 120 of about 6,753,342 (308)

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Trayectorias de paternidades homosexuales en Chile

Revista Latinoamericana de Estudios de Familia
this article exposes the trajectory regarding the process of configuration of homosexual parenthood in men who were fathers in previous heterosexual relationships.
Gonzalo Soto-Guzmán, Javier Ruiz-Ríos, Mladen Matulic-Cvitanic   +2 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Holocene distribution of Octodontid rodents in central Chile Distribución holocénica de roedores octodóntidos en Chile central

Revista Chilena de Historia Natural, 2003
We describe the Holocene distribution of the Octodontids Aconaemys fuscus, Octodon bridgesi, O. degus, O. lunatus, O. pacificus and Spalacopus cyanus from Central Chile. We compared ancient and present day ranges.
BÁRBARA SAAVEDRA, JAVIER A SIMONETTI
doaj  

Tornado Seasonality in Central‐Southern Chile

Geophysical Research Letters
AbstractTornado records in Chile show an apparent seasonality with a peak between May and June. We study this seasonality in central‐south and austral Chile by analyzing three indicators of tornado environments: vorticity generation parameter (VGP), storm‐relative helicity (SRH) and mean relative humidity . Annual cycles of VGP, SRH and show favorable
V. Caballero‐Morán, R. Rondanelli
openaire   +2 more sources

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

ZELUS CERVICALIS STÅL (HEMIPTERA: REDUVIIDAE: HARPACTORINAE), APORTE NEARTICO A LA ENTOMOFAUNA INTRODUCIDA EN CHILE ZELUS CERVICALIS STÅL (HEMIPTERA: REDUVIIDAE: HARPACTORINAE), NEARCTIC APORT TO INTRODUCED CHILEAN ENTOMOFAUNA

Gayana, 2004
Se da a conocer el establecimiento en Chile de Zelus cervicalis Stål, 1872, cuya introducción reciente en el país se asocia al tráfico comercial. Se entrega una breve caracterización, sinonimia, referencias bibliográficas, distribución geográfica ...
Mario Elgueta, Diego L. Carpintero
doaj  

Representaciones de las personas mayores en los estudios sobre migraciones, cuidados y envejecimiento

Si Somos Americanos
Este artículo tiene como objetivo ofrecer un panorama general sobre el tratamiento dado a las personas mayores en la literatura sobre migraciones latinoamericanas y caribeñas, el envejecimiento y la organización local/transnacional de los cuidados, desde
Herminia Gonzálvez-Torralbo, Ariany da Silva Villar   +1 more
doaj   +1 more source

Single‐cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max

Advanced Science, EarlyView.
Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang, Yu Geng, Xinyu Guo, Chen Wang, Yongjing Sun, Luqi Liu, Li Liu, QianQian Gao, XinFang Zhu, Hongxiang Cao, Gengshuo Zhang, Yunxia Liu, Guobin Zhang, Baoyin Chen, Jinfei Zhang, Xin Hou, Xiaoming Li, Dajian Zhang   +17 more
wiley   +1 more source