Results 131 to 140 of about 6,753,342 (308)
Estimating the output gap in times of COVID-19
Latin American Journal of Central BankingWe extend a standard multivariate filter used to estimate the Output Gap (OG) in Chile to account for large economic shocks, such as those observed during the COVID-19 crisis. We propose two methodological extensions. First, we introduce exogenous supply
Luigi Durand, Jorge Alberto Fornero
doaj +1 more source
Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance
Advanced Science, EarlyView.Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer +9 more
wiley +1 more source
Universidad de Chile realiza sus 8vas Jornadas Bibliotecarias
, 2009 "Nuestro PAPEL en el acceso de la Información DIGITAL" es el lema de una nueva versión de este encuentro de carácter anual que el martes 20 de enero reunirá a los bibliotecarios de la Universidad de Chile, a partir de las 09:30 hrs.
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Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
Homecoming parade float; Phi Beta float; "Central Will Star"; one female student sitting on float
Homecoming parade float built by Phi Beta float carries a female student passenger in costume through Fayette, Mo. The float reads, "Central Will Star".
Central Methodist University, Smiley Memorial Library
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Exchange Rate Policy in Chile: From the Band to Floating and Beyond [PDF]
As many countries worldwide, Chile has experienced virtually all the menu of options of exchange rate policies in the last 40 years – with the sole exception of giving up its national currency.
Matías Tapia, Felipe G. Morandé
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Matronería ActualResumen: Las Infecciones de Transmisión Sexual constituyen un problema de salud pública a nivel mundial, afectando principalmente a jóvenes, grupo en el cual se observa un incremento de conductas sexuales de riesgo.
Haylyn Sarria +2 more
doaj +1 more source
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source
Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy
Advanced Science, EarlyView.This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang +5 more
wiley +1 more source
Easter Island (Chile) [cartographic material].
, 1986 Relief shown by shading and spot heights.; Includes inset showing Easter Island's location in relation to Chile.; Shipping list no.: 86-738-P.; "800488 (A05824) 7-86."; Map of Easter Island showing region capitals, roads, tracks, and stone statues (moai).
United States. Central Intelligence Agency.
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