Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Fragaria ananassa DAM4 expression correlates with vegetative growth during semi-dormancy breaking. [PDF]
PlantaDavid S +4 more
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Breeding Achievements and Future Prospects of Low-chill Peaches in Taiwan
, 2014 臺灣桃樹栽培生產主要以高山和平地兩種生產類型，政府為減緩高山墾殖對環境所造成的缺失，積極支持桃樹不區化的品種改良研發，營造環境親和型的桃樹永續發展產業。農試所1996年以來以人工雜交授粉19萬以上的花朵，培育近2萬株實生後代。主要育種目標為育成低需冷量、低酸、早熟、大果、外觀鮮豔、品質優良的早、中、晚熟平地水蜜桃新品種。經淘汰選拔，多年來本所已命名推廣’台農甜蜜‘、’春蜜‘、’夏蜜‘及春豐’及‘紅玉’等5個新品種，經品種授權、繁殖及推廣，目前新品種約佔總栽培面的6成以上。為增加桃果實類丑的多樣性，油桃 ...
歐錫坤;宋家瑋;陸明德 +1 more
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Slow Harm After Dobbs v. Jackson Women's Health Organization: An Analytic Scoping Review of How Data and Surveillance Infrastructures Reshape Emergency Obstetric Care. [PDF]
CureusAjit A, Reddy V.
europepmc +1 more source
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza +19 more
wiley +1 more source
Is It Cold Enough? Effects of Artificial and Natural Chilling on Budbreak and Frost Hardiness in Acer saccharum (Marsh.). [PDF]
Physiol PlantMura C +5 more
europepmc +1 more source
Impact of Chill and Heat Exposures under Diverse Climatic Conditions on Peach and Nectarine Flowering Phenology. [PDF]
Plants (Basel), 2023 Drogoudi P +17 more
europepmc +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source