Results 141 to 150 of about 10,407 (325)
Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis
Advanced Science, EarlyView.In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Electron Microscopic Study on the Spermatogenesis of Chimaera, Chimaera phantasma
, 1983 Comparing with the fine structure of spermatogenic cell of selachians and oter vertebrates, that of the chimaera was observed with light and electron microscopes. The origin of chimaera testis differed essentially from that of selachians.
Mizue, Kazuhiro +3 more
core
Advanced Science, EarlyView.This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim +10 more
wiley +1 more source
Advanced Science, EarlyView.sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang +7 more
wiley +1 more source
Zur Anatomie und Histologie der Chimaera monstrosa
ZUR ANATOMIE UND HISTOLOGIE DER CHIMAERA MONSTROSA Archiv für Anatomie, Physiologie und wissenschaftliche Medicin (-) Archiv für Anatomie, Physiologie und wissenschaftliche Medicin (-) Zur Anatomie und Histologie der Chimaera monstrosa (
Leydig, Franz
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, 2020 Подорога Валерий Александрович. Рене Декарт и Ars chimaera [Электронный ресурс] / В. А. Подорога// Культура и форма : к 60-летию А. Л. Доброхотова : сб. науч. тр. / Гос. ун-т Высш. шк. экономики. - М. : ГУ ВШЭ, 2010. - С.
Подорога Валерий Александрович
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Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion
Advanced Science, EarlyView.The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li +10 more
wiley +1 more source
Chimaera monstrosa Linnaeus, 1758, spec. nov.
Chimaera monstrosa [spec. nov.] C. rostro subtus plicis pertusis. Mus. Ad. Fr. 1. p. 53. t. 25. Chimaera. Clus. exot. 136. t. 137. Genus Galei. Will. icht. 57. Galeus acanthias clusii. Raj. pisc. 23. Galeus acanthias.
Linnaeus, Carolus
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Chimaera didierae Kemper 2017, sp. nov.
, 2017 Chimaera didierae, sp. nov. The Falkor Chimaera (Figs. 14–16; Tables 3–4) Holotype. CAS 242334, 825 mm TL, 533 mm BDL, female, Southwestern Indian Ocean, Madagascar Ridge, 34o30’S, 43o10’E, bottom trawl between 1000 m – 1100 m, collector P.J ...
Kemper, Jenny M.
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