Results 221 to 230 of about 10,407 (325)

Consequences of Climate Change on the Emergence of Pathogenic, Environmentally Acquired Nontuberculous Mycobacteria. [PDF]

Open Forum Infect Dis
Koch TN, Banta JA, Wilsey RN, Chan ED, Crooks JL, Honda JR.   +5 more
europepmc   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Pulmonary nontuberculous mycobacterial infection is associated with urinary molybdenum concentrations in a bronchiectasis cohort. [PDF]

Environ Epidemiol
Semancik CS, Ganninger A, Robinson C, Cooper-Bennett S, Fintzi J, Fennelly K, Prevots DR, Lipner EM.   +7 more
europepmc   +1 more source

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Exploiting Methyl Triazenes as Attractive Alternatives to Temozolomide and Dacarbazine for Cancer Therapy. [PDF]

Molecules
Ribeiro Morais G, Nwokolo GC, Lamptey Mills HNL, Wheelhouse RT, Falconer RA.   +4 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Proliferation of CD10⁺ mature plasmacytoid dendritic cells in lymph nodes of patients with chronic non-tuberculous mycobacterial infection: a case report. [PDF]

J Med Case Rep
Zhang L, Jiang J, Chen X, Sun Y, Lu Y.
europepmc   +1 more source

Comparison of culture and culture-free methods for comprehensive identification of mycobacteria: a single-center prospective study. [PDF]

J Clin Microbiol
Hashimoto K, Fukushima K, Matsumoto Y, Saito H, Funauchi A, Hamada N, Yamauchi J, Nitta T, Motooka D, Nii T, Matsuki T, Tsujino K, Miki K, Komukai S, Kumanogoh A, Nakamura S, Kida H.   +16 more
europepmc   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source

Next-generation sequencing of cell-free microbial DNA in blood samples of critically ill children: a single-center experience. [PDF]

Mol Cell Pediatr
Adolph JE, Pentek C, Bauch T, Held C, Brenner T, Felderhoff-Müser U, Grumaz S, Horvatek P, Steindor M, Asar L, Voigt S, Dziobaka J, Dohna-Schwake C, Goretzki SC.   +13 more
europepmc   +1 more source