Results 51 to 60 of about 13,455 (285)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Annals of Clinical Microbiology and Antimicrobials, 2022 Background Disseminated Mycobacterium chimaera infection is an emerging disease in people undergone to cardiothoracic surgery, which need to be suspected also with atypical presentations.
Tommaso Clemente +8 more
doaj +1 more source
, 2018 NASA's OSIRIS-REx and JAXA's Hayabusa2 sample-return missions are currently on their way to encounter primitive near-Earth asteroids (101955) Bennu and (162173) Ryugu, respectively.
Alí-Lagoa, V. +11 more
core +1 more source
Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor [PDF]
, 2014 Passive SR (sarcoplasmic reticulum) Ca2+ leak through the RyR (ryanodine receptor) plays a critical role in the mechanisms that regulate [Ca2+]rest (intracellular resting myoplasmic free Ca2+ concentration) in muscle.
Chen, Yanyi +5 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Emerging Infectious Diseases, 2017 Mycobacterium chimaera was present at high rates (>80%) in heater–cooler units (HCUs) from all 5 thoracic surgery departments in Denmark. Isolates were clonal to HCU-associated isolates from the United States (including some from patients) and United ...
Erik Svensson +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Mycobacterium chimaera Pulmonary Disease in Cystic Fibrosis Patients, France, 2010–2017
Emerging Infectious Diseases, 2019 We report Mycobacterium chimaera pulmonary disease in 4 patients given a diagnosis of cystic fibrosis in a university hospital in Montpellier, France. All patients had M.
Romaric Larcher +8 more
doaj +1 more source
Abundances of demersal sharks and chimaera from 1994-2009 scientific surveys in the central Mediterranean sea [PDF]
, 2013 Bibliographic and data gathered in scientific bottom trawl surveys carried out off the Southern Coasts of Sicily (Mediterranean Sea), from 1994 to 2009 and between a depth of 10 and 800 m, were analysed in order to prepare a checklist of demersal sharks ...
Dimech, Mark +3 more
core +2 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source