Results 51 to 60 of about 7,776 (287)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
First Australian case of disseminated Mycobacterium chimaera infection post-cardiothoracic surgery
, 2017 A 68 year old female patient was diagnosed with disseminated Mycobacterium chimaera infection 13 months following open cardiothoracic surgery that involved the insertion of a mitral annuloplasty ring.
Playford, EG +3 more
core +1 more source
Identification of Mycobacterium chimaera in heater-cooler units in China [PDF]
, 2018 A global outbreak of infections due to Mycobacterium chimaera has been linked to the LivaNova (formerly Sorin) 3 T heater-cooler units (HCUs). We performed a study to investigate M. chimaera from HCUs in China.
Zhiyong Zong +11 more
core +1 more source
Mycobacterium chimaera Pulmonary Disease in Cystic Fibrosis Patients, France, 2010–2017
Emerging Infectious Diseases, 2019 We report Mycobacterium chimaera pulmonary disease in 4 patients given a diagnosis of cystic fibrosis in a university hospital in Montpellier, France. All patients had M.
Romaric Larcher +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Chimaera monstrosa Linnaeus 1758
, 2015 Chimaera monstrosa Linnaeus, 1758 Chimaera monstrosa Linnaeus 1758: 236. Type locality: Atlantic Ocean. Chimaera monstrosa, Goren & Galil, 1997: 197. Distribution. Northeastern Atlantic and Mediterranean; depth range 40–1000 m.
Galil, Bella S., Goren, Menachem
core +1 more source
Annals of Clinical Microbiology and Antimicrobials, 2022 Background Disseminated Mycobacterium chimaera infection is an emerging disease in people undergone to cardiothoracic surgery, which need to be suspected also with atypical presentations.
Tommaso Clemente +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Emerging Infectious Diseases, 2017 Mycobacterium chimaera was present at high rates (>80%) in heater–cooler units (HCUs) from all 5 thoracic surgery departments in Denmark. Isolates were clonal to HCU-associated isolates from the United States (including some from patients) and United ...
Erik Svensson +5 more
doaj +1 more source