Results 41 to 50 of about 136,848 (282)
Journal of Modern Science, 2023 Objective: The research objective is to indicate current priorities of the European Commission in funding modern technologies that enhance situational awareness and preparedness for CBRN events in urban areas.
Paweł Gromek, Łukasz Szklarski
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Virtual reality experience in haemato-oncology patients—technical evaluation (ViREB-TE)
BMC Digital HealthPurpose Virtual reality (VR) is increasingly being used in health care. However, its use as part of therapy during prolonged inpatient treatments is less well established. This study assessed the experience of hemato-oncology inpatients, their caregivers
Rob Boots +11 more
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Journal of Medicinal Chemistry, 2017 Here we report the development of a proteolysis targeting chimera (PROTAC) based on the combination of the unique features of the sirtuin rearranging ligands (SirReals) as highly potent and isotype-selective Sirt2 inhibitors with thalidomide, a bona fide
M. Schiedel +9 more
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
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Вавиловский журнал генетики и селекции, 2021 Cotyledon and leaf explants of two spring rapeseed varieties were transformed with Agrobacterium tumefaciens harboring a genetic construct with the gfp marker gene.
G. N. Raldugina +3 more
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Chimera states in brain networks: Empirical neural vs. modular fractal connectivity. [PDF]
Chaos, 2017 Complex spatiotemporal patterns, called chimera states, consist of coexisting coherent and incoherent domains and can be observed in networks of coupled oscillators.
T. Chouzouris +5 more
semanticscholar +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
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ЭФФЕКТИВНЫЙ ПОДХОД К СОЗДАНИЮ ХИМЕР ПТИЦ
Cifra: Биологические наукиДальнейший прогресс в птицеводстве может быть достигнут при использовании современных методов биотехнологии, таких как клеточная инженерия. Усовершенствования клеточных технологий позволяют создавать химерные организмы.
Терлецкий В.П. +1 more
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Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
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