Results 201 to 210 of about 115,586 (310)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Editorial: Bridging computation, biophysics, medicine, and engineering in neural circuits. [PDF]

Front Neural Circuits
Kamiya H, Yamamoto H, Soriano J, Sato S, Omori T.   +4 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Functional xenogeneic hematopoietic cells maintaining donor-dominant identity and immune tolerance enable therapy. [PDF]

Exp Hematol Oncol
Xiong S, Zhou R, Wei C, Wang X, Tang Y, Dong L, Yu P, Pei D, Chen Z, Chen SJ, Cheng L.   +10 more
europepmc   +1 more source

Pursuing Library Visions or Chimeras in Berlin? A Review ofThe Future of the State Library in Berlin [PDF]

, 1999
R.L. Cope
openalex   +1 more source

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Detection of PCR chimeras in adaptive immune receptor repertoire sequences. [PDF]

Bioinformatics
Chernyshev M, Stålmarck A, Corcoran M, Karlsson Hedestam GB, Murrell B.   +4 more
europepmc   +1 more source

Impact of pulse exposure on chimera state in ensemble of FitzHugh–Nagumo systems [PDF]

Elena Rybalova, Nadezhda Semenova
openalex   +1 more source

Multiparametric Bioresorbable Sensor for Doxorubicin Detection via Molecularly Imprinted Synthetic Receptors

Advanced Science, EarlyView.
A biodegradable molecularly imprinted polymer porous silica sensor enables dual optical readout of doxorubicin via fluorescence and effective optical thickness shifts. The combined transduction mechanisms provide enhanced reliability and quantitative accuracy over clinically relevant concentrations, representing a step toward transient implantable ...
Martina Corsi, Tiziano Di Giulio, Eleonora Vandini, Muhammad Ibrar Asif, Eleonora Daini, Antonietta Vilella, Giuseppina Leo, Alessandra Ottani, Cosimino Malitesta, Daniela Giuliani, Elisabetta Mazzotta, Giuseppe Barillaro   +11 more
wiley   +1 more source

Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells. [PDF]

Sci Immunol
Saravia J, Chapman NM, Sun Y, Meng X, Risch I, Li W, Guy C, Shi H, Hu H, Dhungana Y, Li J, You Z, Kc A, Lim SA, Raynor JL, Shrestha S, Norton EG, La Grange SE, Robinson CG, Vogel P, Chi H.   +20 more
europepmc   +1 more source