Results 21 to 30 of about 15,238,642 (306)

CAR-T Therapy in Lymphoma Patients With Coexisting Cardiomyopathy or Cardiac Lymphomatous Involvement

JACC: Case Reports, 2023
Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the management of aggressive hematologic malignancies. However, its role in patients with lymphoma and cardiac metastasis or cardiomyopathy remains undefined due to potentially life ...
Choon Ta Ng, MBBS, Hilda M. Gonzalez Bonilla, MD, Ian Chang, MD, M. Tun Aung, MD, Jennifer J. Gile, MD, Naveen L. Pereira, MD, Jose C. Villasboas Bisneto, MD, Patrick B. Johnston, MD, Hector R. Villarraga, MD, Martin G. Rodriguez-Porcel, MD, Grace Lin, MD, Yi Lin, MD, PhD, Joerg Herrmann, MD   +12 more
doaj   +1 more source

Combinatorial functions of two chimeric antibodies directed to human CD4 and one directed to the a-chain of the human interleukin-2 receptor [PDF]

, 1992
The general feasibility of chimerization of monoclonal antibodies (mAbs) has already been shown for a large number of them. In order to evaluate in vitro parameters relevant to immunosuppressive therapy, we have chimerized and synthesized two anti-CD4 ...
Schwirzke, Marina, Kaluzab, Brigitte, Reiter, Christian, Rieber, Ernst Peter, Scheuer, Werner, Flieger, Dimitri, Lenz, Helmut, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H., Riethmüller, Gert   +10 more
core   +1 more source

Chimeric Antigen Receptor T-Cell Therapy for Glioblastoma

Cancers, 2023
Glioblastoma (GBM), the most common primary brain tumor in adults, is characterized by low survival rates and a grim prognosis. Current treatment modalities, including extensive surgical resection, chemotherapy, and radiation therapy, often yield limited success due to the brain’s sensitivity, leading to significant side effects.
Ma, Kun, Hu, Ping
openaire   +2 more sources

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]

, 1992
Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Wegener, Anne-Marie K., Bernard Malissen, Malissen, Bernard, Frederle Luton, Brocker, Thomas, Frédéric Luton, François Letourneur, Frant :is Letourneur, Letourneur, François, Anne-marie K. Wegener, Thomas Brocker, Letourneur, F., Arnd Hoeveler, Thomas Broeker, Brocker, T., Hoeveler, Arnd, Wegener, Am, Hoeveler, A., Luton, Frédéric, Luton, F.   +19 more
core   +1 more source

Chimeric Antigen Receptor-T Cells: A Pharmaceutical Scope [PDF]

Frontiers in Pharmacology, 2021
Cancer is among the leading causes of death worldwide. Therefore, improving cancer therapeutic strategies using novel alternatives is a top priority on the contemporary scientific agenda. An example of such strategies is immunotherapy, which is based on teaching the immune system to recognize, attack, and kill malignant cancer cells.
Alejandrina Hernández-López, Mario A. Téllez-González, Mario A. Téllez-González, Paul Mondragón-Terán, Angélica Meneses-Acosta   +4 more
openaire   +3 more sources

Research Progress of Multi-target CAR-T Cell Therapy for Cancer

Zhongliu Fangzhi Yanjiu, 2022
Chimeric antigen receptor T cell (CAR-T) is a kind of adoptive cell immunotherapy, in which T cells are genetically modified to exert targeted killing effect on tumors.
JIANG Yao, WEN Weihong, YANG Fa, NIE Disen, ZHANG Wuhe, QIN Weijun   +5 more
doaj   +1 more source

Mesothelin-targeting chimeric antigen receptor–modified T cells by transposon system suppress the growth of bile duct carcinoma

Tumor Biology, 2017
Chimeric antigen receptor modified T cell–based immunotherapy is revolutionizing the field of cancer treatment. However, its potential in treating bile duct carcinoma has not been fully explored.
Jie-Ying Xu, Zhen-Long Ye, Du-Qing Jiang, Jiang-Chuan He, Yong-Mei Ding, Lin-Fang Li, Sai-Qun Lv, Ying Wang, Hua-Jun Jin, Qi-Jun Qian   +9 more
doaj   +1 more source

Chimeric antigen receptor T cell structure, its manufacturing, and related toxicities; A comprehensive review

Advances in Cancer Biology - Metastasis, 2022
Cancer is the leading cause of death globally after cardiovascular diseases. Conventional therapeutic strategies have had minimal success rate. Recently, immunotherapy, particularly chimeric antigen receptor T cells (CAR T cells), has emerged as the most
Ubaid Ahmad, Zafran Khan, Daniya Ualiyeva, Obed Boadi Amissah, Zohaib Noor, Asaf Khan, Nasib Zaman, Marwa Khan, Ayub Khan, Babar Ali   +9 more
doaj   +1 more source

A novel predictive algorithm to personalize autologous T-cell harvest for chimeric antigen receptor T-cell manufacture. [PDF]

, 2023
BACKGROUND AIMS The most widely accepted starting materials for chimeric antigen receptor T-cell manufacture are autologous CD3+ T cells obtained via the process of leukapheresis, also known as T-cell harvest. As this treatment modality gains momentum
O'Reilly, Maeve A, Roddie, Claire, Neill, Lorna, Malhi, Aman, Ings, Stuart, Balsa, Carmen, Peggs, Karl S, Keane, Helen, Jalowiec, Katarzyna, Cheok, Kathleen P L   +9 more
core   +1 more source

Drug functional remapping: a new promise for tumor immunotherapy

Frontiers in Oncology
The research and development of new anti-cancer drugs face challenges such as high costs, lengthy development cycles, and limited data on side effects.
Jiayi Dong, Jiayi Dong, Jiayi Dong, Ting Su, Ting Su, Ting Su, Ting Su, Jiexiong Wu, Yu Xiang, Yu Xiang, Yu Xiang, Yu Xiang, Minghan Song, Minghan Song, Minghan Song, Canfeng He, Canfeng He, Canfeng He, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Yubin Yang, Yubin Yang, Size Chen, Size Chen, Size Chen, Size Chen   +27 more
doaj   +1 more source