Results 61 to 70 of about 38,150 (242)

Weaning of immunosuppression in long - Term liver transplant recipients [PDF]

, 1995
Seventy-two long-surviving liver transplant recipients were evaluated prospectively, including a baseline allograft biopsy for weaning off of immunosuppression.
Abu-Elmagd, K, Demetris, AJ, Ebert, F, Flynn, B, Fung, JJ, McMichael, J, Ramos, H, Reinsmoen, N, Reyes, J, Starzl, TE, Tzakis, A, Zeevi, A   +11 more
core   +1 more source

The importance of MHC class II in allogeneic bone marrow transplantation and chimerism-based solid organ tolerance in a rat model.

PLoS ONE, 2020
Mixed hematopoietic chimerism enables donor-specific tolerance for solid organ grafts. This study evaluated the influence of different serological major histocompatibility complex disparities on chimerism development, graft-versus-host disease incidence ...
Kai Timrott, Oliver Beetz, Felix Oldhafer, Jürgen Klempnauer, Florian W R Vondran, Mark D Jäger   +5 more
doaj   +1 more source

Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy

Asia-Pacific Journal of Clinical Oncology, EarlyView.
We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija, Fiona Kerr, Hazel Gough, Johnathan Soggee, Laurence C. Cheung, Rishi S. Kotecha, Shanti Ramachandran   +6 more
wiley   +1 more source

Evidence for engraftment of human bone marrow cells in non-lethally irradiated baboons [PDF]

, 1997
Background. Prior to organ harvesting, an attempt was made to modulate the donor's immune responses against prospective xenogeneic recipients by infusion of 'recipient-type' bone marrow. Methods.
Fontes, P, Fung, JJ, Rao, AS, Ricordi, C, Rogers, J, Starzl, TE, Trucco, M, Zeevi, A   +7 more
core   +1 more source

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy

Advances in Hematology, 2017
In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu ...
Shatha Farhan, Michael Bazydlo, Klodiana Neme, Nancy Mikulandric, Edward Peres, Nalini Janakiraman   +5 more
doaj   +1 more source

Treosulfan–fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study

British Journal of Haematology, EarlyView.
Summary Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative therapy for severe combined immunodeficiency (SCID). Conditioning improves donor engraftment and freedom from immunoglobulin replacement (IgR) but increases the risks of acute and late toxicity. Treosulfan, a reduced toxicity alkylating agent, has emerged as an alternative
Su Han Lum, Sinéad Greener, Irum Latif Memon, Persis Amrolia, Zohreh Nademi, Robert Chiesa, Juliana Silva, Helen Young, Stephen Owens, Eleri Williams, Khuen Foong Ng, Terry Flood, Andrew R Gennery, Sophie Hambleton, Kanchan Rao, Mary Slatter   +15 more
wiley   +1 more source

A Blind Spot in Post‐Liver Transplant Care: Correlation and Causation in Immunosuppression, Drug Monitoring, and Immune Checkpoint Inhibitor‐Related Rejection

Health Care Science, EarlyView.
Björn Nashan
wiley   +1 more source

MYC Addiction as a Targetable Vulnerability in Nelarabine‐Resistant T‐Cell Acute Lymphoblastic Leukemia

Cancer Science, EarlyView.
MYC drives nelarabine resistance in T‐ALL via a hyperactive transcriptional program. Pharmacological degradation of BET proteins dismantles this addiction, restoring drug sensitivity and extending survival in vivo. ABSTRACT Acquired resistance represents a fundamental obstacle limiting the long‐term efficacy of cancer chemotherapy.
Jingjing Gao, Chunxu Lin, Suchang Chen, Qi Mo, Chu Bao, Huali Deng, Ziyin Chen, Weichao Hao, Luyong Zhang, Min Wei   +9 more
wiley   +1 more source

Distinct Characteristics and Features of Allogeneic Chimerism in the NOD Mouse Model of Autoimmune Diabetes

Cell Transplantation, 2002
The adaptation of allogeneic chimerism in treatment of autoimmune diabetes has been shown as a promising approach in numerous studies in both experimental and clinical settings.
Tatiana D. Zorina M.D., Ph.D., Vladimir M. Subbotin, Suzanne Bertera, Angela M. Alexander, Catherine Haluszczak, Alexis J. Styche, Massimo Trucco   +6 more
doaj   +1 more source

An optimization of protocol for mixed chimerism induction in mice model.

Folia Histochemica et Cytobiologica, 2010
Studies on mixed chimerism are currently focused primarily on obtaining less toxic conditioning protocols. With these issues in mind, we have undertaken the attempt to optimize the procedure of mixed chimerism induction in mice.
B Machaliński, M Walczak, Ch Schmidt, V Dziedziejko, M Hałasa, E Pius, K Grymuła, M Baśkiewicz-Masiuk   +7 more
doaj   +1 more source