Results 61 to 70 of about 31,237 (196)

Chimerism in Myeloid Malignancies following Stem Cell Transplantation Using FluBu4 with and without Busulfan Pharmacokinetics versus BuCy

Advances in Hematology, 2017
In the era of precision medicine, the impact of personalized dosing of busulfan is not clear. We undertook a retrospective analysis of 78 patients with myeloid malignancies who received fludarabine and busulfan (FluBu4) with or without measuring Bu ...
Shatha Farhan, Michael Bazydlo, Klodiana Neme, Nancy Mikulandric, Edward Peres, Nalini Janakiraman   +5 more
doaj   +1 more source

Predicting Outcomes of Rat Vascularized Composite Allotransplants through Quantitative Measurement of Chimerism with PCR-Amplified Short Tandem Repeat

Journal of Immunology Research, 2020
Chimerism has been associated with the induction and maintenance of tolerance to vascularized composite allotransplants (VCA). Although most VCA studies have examined chimerism using flow cytometry, we proposed that precision in the measurement of ...
Hui-Yun Cheng, Xiao-Ting Huang, Chih-Fan Lin, Nidal F. AL Deek, Ling-Yi Shih, Cheng-Hung Lin, Fu-Chan Wei   +6 more
doaj   +1 more source

Polymorphisms for the size of heterochromatic regions allow sex-independent quantification of post-BMT chimerism targeting metaphase and interphase cells

Haematologica, 1999
BACKGROUND AND OBJECTIVE: Fully quantitative cytological techniques for the analysis of hemopoietic chimerism are very limited and largely restricted to sex-chromosome detection after sex-mismatched bone marrow transplants (BMTs).
I Buno, JL Diez-Martin, C Lopez-Fernandez, JL Fernandez, J Gosalvez   +4 more
doaj  

Chimerism status is a useful predictor of relapse after allogeneic stem cell transplantation for acute leukemia

Haematologica, 2003
BACKGROUND AND OBJECTIVES: The role of hematopoietic chimerism after allogeneic stem cell transplantation (SCT) for acute leukemia remains controversial.
M Barrios, A Jimenez-Velasco, J Roman-Gomez, ME Madrigal, JA Castillejo, A Torres, A Heiniger   +6 more
doaj  

Validation of a Next Generation Sequencing based method for chimerism analysis in clinical practice

, 2022
Hematopoietic stem cell transplantation (HSCT) is used to treat patient with hematological diseases such as leukemia and genetic conditions such as sickle cell anemia. After HSCT the patients are supervised for signs of relapse of disease or rejection of
Högberg, Maria
core   +1 more source

Distinct Characteristics and Features of Allogeneic Chimerism in the NOD Mouse Model of Autoimmune Diabetes

Cell Transplantation, 2002
The adaptation of allogeneic chimerism in treatment of autoimmune diabetes has been shown as a promising approach in numerous studies in both experimental and clinical settings.
Tatiana D. Zorina M.D., Ph.D., Vladimir M. Subbotin, Suzanne Bertera, Angela M. Alexander, Catherine Haluszczak, Alexis J. Styche, Massimo Trucco   +6 more
doaj   +1 more source

Frequency of chimerism in populations of the kelp Lessonia spicata in central Chile.

PLoS ONE, 2017
Chimerism occurs when two genetically distinct conspecific individuals fuse together generating a single entity. Coalescence and chimerism in red seaweeds has been positively related to an increase in body size, and the consequent reduction in ...
Alejandra V González, Bernabé Santelices   +1 more
doaj   +1 more source

Mixed chimerism after bone marrow transplantation for thalassemia major

Haematologica, 2002
Thirty-four thalassemia patients were studied for chimerism by fluorescent in situ hybridization or variable number tandem repeats after bone marrow transplantation. Mixed chimerism was detected in 9 patients with host cells ranging from 4 to 56%.
CK Li, KW Chik, KS Tsang, H Pong, MM Shing, PM Yuen   +5 more
doaj  

Hematopoietic chimerism and donor-specific skin allograft tolerance after non-genotoxic CD117 antibody-drug-conjugate conditioning in MHC-mismatched allotransplantation

Nature Communications, 2019
Transplantation of allogeneic bone marrow helps establish chimerism that may induce tolerance to tissue grafts. Here the authors show that a CD117-antibody-drug-conjugate helps precondition the recipients for inducing mixed chimerism and allo-tolerance ...
Zhanzhuo Li, Agnieszka Czechowicz, Amelia Scheck, Derrick J. Rossi, Philip M. Murphy   +4 more
doaj   +1 more source

An optimization of protocol for mixed chimerism induction in mice model.

Folia Histochemica et Cytobiologica, 2010
Studies on mixed chimerism are currently focused primarily on obtaining less toxic conditioning protocols. With these issues in mind, we have undertaken the attempt to optimize the procedure of mixed chimerism induction in mice.
B Machaliński, M Walczak, Ch Schmidt, V Dziedziejko, M Hałasa, E Pius, K Grymuła, M Baśkiewicz-Masiuk   +7 more
doaj   +1 more source