Results 41 to 50 of about 38,150 (242)

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Predicting Outcomes of Rat Vascularized Composite Allotransplants through Quantitative Measurement of Chimerism with PCR-Amplified Short Tandem Repeat

Journal of Immunology Research, 2020
Chimerism has been associated with the induction and maintenance of tolerance to vascularized composite allotransplants (VCA). Although most VCA studies have examined chimerism using flow cytometry, we proposed that precision in the measurement of ...
Hui-Yun Cheng, Xiao-Ting Huang, Chih-Fan Lin, Nidal F. AL Deek, Ling-Yi Shih, Cheng-Hung Lin, Fu-Chan Wei   +6 more
doaj   +1 more source

Evidence for Recipient-Derived Cells in Peribiliary Glands and Biliary Epithelium of the Large Donor Bile Ducts After Liver Transplantation

Frontiers in Cell and Developmental Biology, 2020
IntroductionChimerism after orthotopic liver transplantation (OLT) has largely been investigated in intrahepatic cellular constituents. However, little is known about chimerism in the extrahepatic and large intrahepatic bile ducts.
Iris E. M. de Jong, Iris E. M. de Jong, Michael E. Sutton, Michael E. Sutton, Marius C. van den Heuvel, Annette S. H. Gouw, Robert J. Porte   +6 more
doaj   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Kidney versus Islet Allograft Survival after Induction of Mixed Chimerism with Combined Donor Bone Marrow Transplantation

Cell Transplantation, 2016
We have previously reported successful induction of transient mixed chimerism and long-term acceptance of renal allografts in MHC mismatched nonhuman primates. In this study, we attempted to extend this tolerance induction approach to islet allografts. A
Tetsu Oura, Dicken S. C. Ko, Svjetlan Boskovic, John J. O'neil, Vaja Chipashvili, Maria Koulmanda, Kiyohiko Hotta, Kento Kawai, Ognjenka Nadazdin, R. Neal Smith, A. B. Cosimi, Tatsuo Kawai M.D., Ph.D.   +11 more
doaj   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice [PDF]

, 2016
The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1-/-) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR
Irvine, Elaine E., Michie, Alison M., Pedroni, Silvia M.A., Selman, Colin, Sinclair, Amy, Withers, Dominic J.   +5 more
core   +2 more sources

Prolonged Survival of Subcutaneous Allogeneic Islet Graft by Donor Chimerism without Immunosuppressive Treatment

International Journal of Endocrinology, 2017
The aim of this study was to investigate whether tolerance-induced protection of islets in the renal subcapsular space can also prevent subcutaneous allogeneic islets from being rejected.
Brend Ray-Sea Hsu, Shin-Huei Fu, Aline Yen Ling Wang   +2 more
doaj   +1 more source

Quantification of mixed chimerism allows early therapeutic interventions

Revista Brasileira de Hematologia e Hemoterapia, 2014
Hematopoietic stem cell transplantation is the curative option for patients with myelodysplastic syndrome; however, it requires a long post-transplantation follow-up.
Jóice Merzoni, Gisele Menezes Ewald, Alessandra Aparecida Paz, Liane Esteves Daudt, Luiz Fernando Job Jobim   +4 more
doaj   +1 more source

Intestinal transplantation under tacrolimus monotherapy after perioperative lymphoid depletion with rabbit anti-thymocyte globulin (thymoglobulin®) [PDF]

, 2005
Modifications in the timing and dosage of immunosuppression can ameliorate the morbidity and mortality that has prevented widespread use of intestinal transplantation (ITx) in children.
Abu-Elmagd, K, Bond, GJ, Macedo, C, Mazariegos, GV, Murase, N, Peters, J, Reyes, J, Sindhi, R, Starzl, TE   +8 more
core   +1 more source