Results 31 to 40 of about 38,150 (242)

The predictive value of T-cell chimerism for disease relapse after allogeneic hematopoietic stem cell transplantation

Frontiers in Immunology
IntroductionChimerism is closely correlated with disease relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, chimerism rate is dynamic changes, and the sensitivity of different chimerism requires further research ...
Zhipeng Li, Jing Wang, Lei Deng, Ximin Liu, Fanjun Kong, Yuerong Zhao, Yixi Hou, Fang Zhou   +7 more
doaj   +1 more source

Stability of Chimerism in Non-Obese Diabetic Mice Achieved By Rapid T Cell Depletion Is Associated With High Levels of Donor Cells Very Early After Transplant

Frontiers in Immunology, 2018
Stable mixed hematopoietic chimerism is a robust method for inducing donor-specific tolerance with the potential to prevent rejection of donor islets in recipients with autoimmune type-1 diabetes.
Jiaxin Lin, Jiaxin Lin, William F. N. Chan, Louis Boon, Colin C. Anderson, Colin C. Anderson, Colin C. Anderson   +6 more
doaj   +1 more source

Prenatal Tolerance Induction: Relationship between Cell Dose, Marrow T-Cells, Chimerism, and Tolerance

Cell Transplantation, 2008
It was reported that the dose of self-antigens can determine the consequence of deletional tolerance and donor T cells are critical for tolerance induction in mixed chimeras.
Jeng-Chang Chen M.D., Ming-Ling Chang, Shiu-Feng Huang, Pei-Yeh Chang, Marcus O. Muench, Ren-Huei Fu, Liang-Shiou Ou, Ming-Ling Kuo   +7 more
doaj   +1 more source

Allograft and Xenograft Acceptance under FK‐506 and Other Immunosuppressant Treatment [PDF]

, 1993
We will focus on two issues, both involving, but not confined to FK-506: first, the meaning of the graft acceptance, which is, after all, the objective of immunosuppression for the transplant surgeon; and second, how to take the next great step of ...
Kahan B. D., Kashiwagi N., Murase N., Murase N., Porter K. A., Starzl T. E., Starzl T. E., Steinmuller D., Wilson W. E. C., Zeevi A.   +9 more
core   +1 more source

Validation of next-generation sequencing-based chimerism testing for accurate detection and monitoring of engraftment in hematopoietic stem cell transplantation

Frontiers in Genetics, 2023
Allogenic hematopoietic stem cell transplantation (allo-HSCT) is a life-saving treatment for various hematological disorders. The success of allo-HSCT depends on the engraftment of donor cells and the elimination of recipient cells monitored through ...
Pramath Kakodkar, Yayuan Zhao, Henry Pan, Fang Wu, Twyla Pearce, Destinie Webster, Mohamed Elemary, Waleed Sabry, Luvinia Kwan, Lindsay Pelzer, Mark Bosch, Karen R. Sherwood, James Lan, Jenny Tran, Robert Liwski, Paul Keown, Ahmed Mostafa, Ahmed Mostafa   +17 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of a quantitative PCR-based method for chimerism analysis of Japanese donor/recipient pairs

Scientific Reports, 2022
Chimerism analysis is a surrogate indicator of graft rejection or relapse after allogeneic hematopoietic stem cell transplantation (HSCT). Although short tandem repeat PCR (STR-PCR) is the usual method, limited sensitivity and technical variability are ...
Keiji Minakawa, Satoshi Ono, Mao Watanabe, Yuka Sato, Saki Suzuki, Shou Odawara, Kinuyo Kawabata, Koki Ueda, Kenneth E. Nollet, Hideki Sano, Takayuki Ikezoe, Atsushi Kikuta, Kazuhiko Ikeda   +12 more
doaj   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Real‐World Outcomes of FLAG‐Ida Regimen in 1079 Adult Patients With First Relapsed/Refractory AML: A PETHEMA Study

American Journal of Hematology, EarlyView.
ABSTRACT In a large multicenter real‐world cohort, we aimed to evaluate outcomes of FLAG‐Ida salvage therapy for relapsed/refractory (R/R) acute myeloid leukemia (AML) and validated the SALFLAGE prognostic score. We analyzed 1079 adults with R/R AML treated across 112 PETHEMA institutions over 26 years (1998–2024), including patients with primary ...
Gaspar Aspas Requena, Rebeca Rodríguez‐Veiga, Cristina Gil, Carmen Botella, Eliana Aguiar, Fernanda Trigo, Mercedes Colorado, Teresa del Bernal del Castillo, Eva Barragan, Mar Tormo, Eduardo Rodríguez Arbolí, Josefina Serrano López, Raimundo García Boyero, Tamara Castaño, Pilar Herrera Puente, Mónica A. Romero Riquelme, María J. Sayas Lloris, Lorenzo Algarra‐Algarra, Carlos Rodriguez‐Medina, Claudia L. Sossa Melo, Jorge Labrador Gomez, Susana Vives, Olga Salamero, María Luz Amigo, Marta Valero Nuñez, Christine Rojas, Francisca Bass, María García‐Fortes, Belén Vidriales Vicente, Marta Polo, Celina Benavente, María D. Madrigal, Marcela Espinoza, Manuel Pérez‐Encinas, María L. Amador Barciela, Guiomar Bautista, Antonio Solana‐Altabella, Isabel Cano‐Ferri, Rafael Colmenares, Patricia García‐Ramírez, Francisco Ibáñez Alis, Manuel Barrios García, Gabriela Rodríguez‐Macías, Miguel López, Ana Yurena Oliva Hernández, Carlos Javier Cerveró, David Martínez‐Cuadrón, Pedro Chorão, Juan M. Bergua Burgues, Pau Montesinos   +49 more
wiley   +1 more source

Immune status of recipients following bone marrow - Augmented solid organ transplantation [PDF]

, 1995
It has been postulated that the resident “passenger” leukocytes of hematolymphoid origin that migrate from whole organ grafts and subsequently establish systemic chimerism are essential for graft acceptance and the induction of donor-specific ...
Banas, R, Carroll, P, Demetris, J, Dodson, F, Fontes, P, Fung, JJ, Lombardozzi, S, Pappo, O, Pavlick, M, Pham, S, Rao, AS, Shapiro, R, Starzl, TE, Trucco, M, Zeevi, A   +14 more
core   +1 more source