Results 11 to 20 of about 38,150 (242)

Is chimerism associated with cancer across the tree of life?

PLoS ONE, 2023
Chimerism is a widespread phenomenon across the tree of life. It is defined as a multicellular organism composed of cells from other genetically distinct entities. This ability to 'tolerate' non-self cells may be linked to susceptibility to diseases like
Stefania E Kapsetaki, Angelo Fortunato, Zachary Compton, Shawn M Rupp, Zaid Nour, Skyelyn Riggs-Davis, Dylan Stephenson, Elizabeth G Duke, Amy M Boddy, Tara M Harrison, Carlo C Maley, Athena Aktipis   +11 more
doaj   +2 more sources

Bone marrow CD34+ molecular chimerism as an early predictor of relapse after allogeneic stem cell transplantation in patients with acute myeloid leukemia

Frontiers in Oncology, 2023
BackgroundMinimal residual disease (MRD) monitoring is an important tool to optimally address post-transplant management of acute myeloid leukemia (AML) patients.MethodsWe retrospectively analyzed the impact of bone marrow CD34+ molecular chimerism and ...
Michele Malagola, Nicola Polverelli, Alessandra Beghin, Federica Bolda, Marta Comini, Mirko Farina, Enrico Morello, Vera Radici, Eugenia Accorsi Buttini, Simona Bernardi, Simona Bernardi, Federica Re, Federica Re, Alessandro Leoni, Alessandro Leoni, Davide Bonometti, Duilio Brugnoni, Arnalda Lanfranchi, Domenico Russo   +18 more
doaj   +1 more source

Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation

Трансплантология (Москва), 2022
Allogeneic hematopoietic stem cells transplantation is one of the effective methods of treating patients with diseases of the blood system.Establishment of complete (100%) donor chimerism is among of the main indicators of successful transplantation in ...
D. S. Dubnyak, N. V. Risinskaya, M. Yu. Drokov, A. B. Sudarikov   +3 more
doaj   +1 more source

Donor/recipient mixed chimerism does not predict graft failure in children with β-thalassemia given an allogeneic cord blood transplant from an HLA-identical sibling

Haematologica, 2008
Background Donor/recipient mixed chimerism has been reported to be associated with an increased risk of graft failure in patients with β-thalassemia given a bone marrow transplant.
Daniela Lisini, Marco Zecca, Giovanna Giorgiani, Daniela Montagna, Rosaria Cristantielli, Massimo Labirio, Pierangela Grignani, Carlo Previderè, Alessandra Di Cesare-Merlone, Giovanni Amendola, Elena Bergami, Angela Mastronuzzi, Rita Maccario, Franco Locatelli   +13 more
doaj   +1 more source

Establishment of Chimerism and Organ Transplant Tolerance in Laboratory Animals: Safety and Efficacy of Adaptation to Humans

Frontiers in Immunology, 2022
The definition of immune tolerance to allogeneic tissue and organ transplants in laboratory animals and humans continues to be the acceptance of the donor graft, rejection of third-party grafts, and specific unresponsiveness of recipient immune cells to ...
Robert Lowsky, Samuel Strober
doaj   +1 more source

Impact of early chimerism status on clinical outcome in children with acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

BMC Cancer, 2019
Background The significance of very early chimerism assessment before day + 28, which is considered the moment of engraftment, is still unclear. In this retrospective study, we evaluated the clinical impact of very early chimerism on the clinical outcome
Monika Lejman, Agnieszka Zaucha-Prażmo, Joanna Zawitkowska, Aleksandra Mroczkowska, Dominik Grabowski, Jerzy R. Kowalczyk, Katarzyna Drabko   +6 more
doaj   +1 more source

Extensive multilineage analysis in patients with mixed chimerism after allogeneic transplantation for sickle cell disease: insight into hematopoiesis and engraftment thresholds for gene therapy

Haematologica, 2020
Although studies of mixed chimerism following hematopoietic stem cell transplantation in patients with sickle cell disease (SCD) may provide insights into the engraftment needed to correct the disease and into immunological reconstitution, an extensive ...
Alessandra Magnani, Corinne Pondarré, Naïm Bouazza, Jeremy Magalon, Annarita Miccio, Emmanuelle Six, Cecile Roudaut, Cécile Arnaud, Annie Kamdem, Fabien Touzot, Aurélie Gabrion, Elisa Magrin, Chloé Couzin, Mathieu Fusaro, Isabelle André, Jean-Paul Vernant, Eliane Gluckman, Françoise Bernaudin, Dominique Bories, Marina Cavazzana   +19 more
doaj   +1 more source

Donor Chimerism of B Cells and Nature Killer Cells Provides Useful Information to Predict Hematologic Relapse following Allogeneic Hematopoietic Stem Cell Transplantation. [PDF]

PLoS ONE, 2015
In this study we investigated the correlation between donor chimerism status and disease relapse following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The chimerism of Fluorescence-activated cell sorter (FACS) sorted CD3+T lymphocytes
Ying Jiang, Liping Wan, Youwen Qin, Xiaorui Wang, Shike Yan, Kuangcheng Xie, Chun Wang   +6 more
doaj   +1 more source

Early relapse prediction after allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia (ALL) using lineage‐specific chimerism analysis

eJHaem, 2022
Relapse is a major cause of treatment failure after hematopoietic stem cell transplantation (HSCT) for acute leukemia. Here, we report a monocentric retrospective study of all HSCTs for B cell acute lymphoblastic leukemia (ALL) performed during the years
Hannes Lindahl, Davide Valentini, Sofie Vonlanthen, Mikael Sundin, Andreas T. Björklund, Stephan Mielke, Dan Hauzenberger   +6 more
doaj   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source