Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001 Induction of mixed chimerism has the potential to overcome the current limitations of transplantation, namely chronic rejection, complications of immunosuppressive therapy and the need for xenografts to overcome the current shortage of allogeneic organs.
M, Sykes, D H, Sachs
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Cell migration and chimerism after whole‐organ transplantation: The basis of graft acceptance [PDF]
, 1993 Improvements in the prevention or control of rejection of the kidney and liver have been largely interchangeable ( 1 , 2 ) and then applicable, with very little modification, to thoracic and other organs.
Demetris, AJ +13 more
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Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients [PDF]
, 1995 Background.: We and others have demonstrated that a low level of donor cell chimerism was present for years after transplantation in tissues and peripheral blood of heart and lung recipients; it was associated, in the latter, with a lower incidence of ...
Abdul S. Rao +34 more
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Chimerism and xenotransplantation: New concepts [PDF]
, 1999 In both transplant and infectious circumstances, the immune response is governed by migration and localization of the antigen. If the antigenic epitopes of transgenic xenografts are sufficiently altered to avoid evoking the destructive force of innate ...
Demetris, AJ +5 more
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Chimerism after organ transplantation [PDF]
, 1997 Recent evidence suggests that passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allograft.
Demetris, AJ +6 more
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An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors. [PDF]
, 2017 Hematopoietic stem cells (HSCs) are considered one of the most promising therapeutic targets for the treatment of various blood disorders. However, due to difficulties in establishing stable maintenance and expansion of HSCs in vitro, their insufficient ...
Ema, Hideo +14 more
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Growth of donor-derived dendritic cells from the bone marrow of murine liver auograft recipients in response to granulocyte/macrophage colony-stimulating factor [PDF]
, 1995 Allografts of the liver, which has a comparatively heavy leukocyte content compared with other vascularized organs, are accepted permanently across major histocompatibility complex barriers in many murine strain combinations without immunosuppressive ...
Fu, F +9 more
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Quantum Randomness is Chimeric [PDF]
Entropy, 2021 If quantum mechanics is taken for granted, the randomness derived from it may be vacuous or even delusional, yet sufficient for many practical purposes. “Random” quantum events are intimately related to the emergence of both space-time as well as the identification of physical properties through which so-called objects are aggregated. We also present a
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Infusion of donor leukocytes to induce tolerance in organ allograft recipients [PDF]
, 1999 To further enhance chimerism, 229 primary allograft recipients have received perioperative intravenous infusion of a single dose of 3 to 6 x 108 unmodified donor bone marrow (BM) cells/kg body weight.
Abu-Elmagd, K +16 more
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Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]
, 1994 Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold +45 more
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