Results 1 to 10 of about 21,476 (115)

Chimerism practices across Canadian transplant centres: review of current standards and variations [PDF]

Frontiers in Transplantation
BackgroundChimerism analysis is used in hematopoietic stem cell transplantation (HSCT) to evaluate donor engraftment and assess underlying disease status.
Matthew Gravina, Kylie Lepic, Brian Leber, Irwin Walker, Tobias Berg, Tobias Berg, Tobias Berg, Wilson Lam, Alejandro Garcia-Horton, Shreyash Dalmia, Daria Grafodatskaya, Darci T. Butcher, Darci T. Butcher, Joseph Alexander Aziz, Michael Radford   +14 more
doaj   +2 more sources

Lineage-Specific Chimerism Analysis After Allogeneic Hematopoietic Cell Transplantation in Patients with Myeloid Neoplasms: Current Evidence and Considerations in the Post-Transplant Cyclophosphamide Setting [PDF]

Biomedicines
Background: Chimerism analysis is a key tool for monitoring donor-cell engraftment and the risk of relapse and graft-versus-host disease (GVHD) following allogeneic hematopoietic cell transplantation (allo-HCT).
Jan Mateusz Zaucha, Jan Maciej Zaucha, Agnieszka Piekarska   +2 more
doaj   +2 more sources

Prospects and Potential for Chimerism Analysis After Allogeneic Hematopoietic Stem Cell Transplantation

Cells
Chimerism analysis after allogeneic hematopoietic stem cell transplantation serves to confirm engraftment, indicate relapse of hematologic malignancy, and attribute graft failure to either immune rejection or poor graft function. Short tandem repeat PCR (
Kazuhiko Ikeda, Koki Ueda, Kenneth Nollet   +2 more
exaly   +3 more sources

Is chimerism associated with cancer across the tree of life?

PLoS ONE, 2023
Chimerism is a widespread phenomenon across the tree of life. It is defined as a multicellular organism composed of cells from other genetically distinct entities. This ability to ‘tolerate’ non-self cells may be linked to susceptibility to diseases like
Stefania E. Kapsetaki, Angelo Fortunato, Zachary Compton, Shawn M. Rupp, Zaid Nour, Skyelyn Riggs-Davis, Dylan Stephenson, Elizabeth G. Duke, Amy M. Boddy, Tara M. Harrison, Carlo C. Maley, Athena Aktipis   +11 more
doaj   +2 more sources

New methods for the quantification of mixed chimerism in transplantation

Frontiers in Immunology, 2023
BackgroundQuantification of chimerism showing the proportion of the donor in a recipient is essential for the follow-up of hematopoietic stem cell transplantation but can also be useful to document an immune tolerance situation after solid organ ...
Christophe Picard, Christophe Picard, Coralie Frassati, Nicem Cherouat, Sandrine Maioli, Philippe Moskovtchenko, Mathilde Cherel, Jacques Chiaroni, Jacques Chiaroni, Pascal Pedini, Pascal Pedini   +10 more
doaj   +1 more source

Donor/recipient mixed chimerism does not predict graft failure in children with β-thalassemia given an allogeneic cord blood transplant from an HLA-identical sibling

Haematologica, 2008
Background Donor/recipient mixed chimerism has been reported to be associated with an increased risk of graft failure in patients with β-thalassemia given a bone marrow transplant.
Daniela Lisini, Marco Zecca, Giovanna Giorgiani, Daniela Montagna, Rosaria Cristantielli, Massimo Labirio, Pierangela Grignani, Carlo Previderè, Alessandra Di Cesare-Merlone, Giovanni Amendola, Elena Bergami, Angela Mastronuzzi, Rita Maccario, Franco Locatelli   +13 more
doaj   +1 more source

Bone marrow CD34+ molecular chimerism as an early predictor of relapse after allogeneic stem cell transplantation in patients with acute myeloid leukemia

Frontiers in Oncology, 2023
BackgroundMinimal residual disease (MRD) monitoring is an important tool to optimally address post-transplant management of acute myeloid leukemia (AML) patients.MethodsWe retrospectively analyzed the impact of bone marrow CD34+ molecular chimerism and ...
Michele Malagola, Nicola Polverelli, Alessandra Beghin, Federica Bolda, Marta Comini, Mirko Farina, Enrico Morello, Vera Radici, Eugenia Accorsi Buttini, Simona Bernardi, Simona Bernardi, Federica Re, Federica Re, Alessandro Leoni, Alessandro Leoni, Davide Bonometti, Duilio Brugnoni, Arnalda Lanfranchi, Domenico Russo   +18 more
doaj   +1 more source

Donor Chimerism of B Cells and Nature Killer Cells Provides Useful Information to Predict Hematologic Relapse following Allogeneic Hematopoietic Stem Cell Transplantation. [PDF]

PLoS ONE, 2015
In this study we investigated the correlation between donor chimerism status and disease relapse following allogeneic hematopoietic stem cell transplantation (allo-HSCT). The chimerism of Fluorescence-activated cell sorter (FACS) sorted CD3+T lymphocytes
Ying Jiang, Liping Wan, Youwen Qin, Xiaorui Wang, Shike Yan, Kuangcheng Xie, Chun Wang   +6 more
doaj   +1 more source

Impact of early chimerism status on clinical outcome in children with acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

BMC Cancer, 2019
Background The significance of very early chimerism assessment before day + 28, which is considered the moment of engraftment, is still unclear. In this retrospective study, we evaluated the clinical impact of very early chimerism on the clinical outcome
Monika Lejman, Agnieszka Zaucha-Prażmo, Joanna Zawitkowska, Aleksandra Mroczkowska, Dominik Grabowski, Jerzy R. Kowalczyk, Katarzyna Drabko   +6 more
doaj   +1 more source

Monitoring of chimerism after allogeneic hematopoietic stem cell transplantation

Трансплантология (Москва), 2022
Allogeneic hematopoietic stem cells transplantation is one of the effective methods of treating patients with diseases of the blood system.Establishment of complete (100%) donor chimerism is among of the main indicators of successful transplantation in ...
D. S. Dubnyak, N. V. Risinskaya, M. Yu. Drokov, A. B. Sudarikov   +3 more
doaj   +1 more source