Results 21 to 30 of about 38,150 (242)

Navigating preemptive and therapeutic donor lymphocyte infusions in advanced myeloid malignancies by high-sensitivity chimerism analysis

open access: yesFrontiers in Oncology, 2022
Preemptive and therapeutic donor lymphocyte infusions (preDLI and tDLI) are widely used in relapsing and relapsed hematopoietic malignancies after allogeneic stem cell transplantation (alloSCT) to enhance the graft-versus-malignancy effect.
Michael Stadler   +16 more
doaj   +1 more source

Chimerism following allogeneic hematopoietic stem cell transplantation

open access: yesКлиническая онкогематология, 2013
Allogenic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for various hematological disorders. Different molecular genetics methods are useful to monitor engraftment, relapse of the underlying disease, rejection of the ...
O. V. Blau
doaj   +1 more source

Correlation of Chimerism with Acute Graft-versus-Host Disease in Rats following Liver Transplantation

open access: yesInternational Journal of Hepatology, 2011
The accurate diagnosis of acute graft-versus-host disease following liver transplantation (LTx-aGVHD) has been hampered. Chimerism appears in the majority of recipients after LT and its significance in the diagnosis of LTx-aGVHD has not been clearly ...
Fei Xue   +5 more
doaj   +1 more source

Late chimerical status after bone marrow transplantation in severe aplastic anemia according to two different preparatory regimens

open access: yesHematology, Transfusion and Cell Therapy, 2018
Background: This study investigated the influence of two conditioning regimens on the chimerical status of 104 patients with acquired severe aplastic anemia.
Marcia Quiroga   +5 more
doaj   +1 more source

Long-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant? [PDF]

open access: yesPLoS ONE, 2016
Long-term stable mixed chimerism is a rare and poorly understood phenomenon post hematopoietic stem cell transplantation. This study aims to shed light on whether the two hematopoietic systems in patients with mixed chimerism remain functional ...
Arwen Stikvoort   +7 more
doaj   +1 more source

Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation

open access: yesHaematologica, 2009
Analysis of donor chimerism is an important diagnostic tool to assess the risk of relapse after allogeneic stem cell transplantation, especially in patients lacking a specific marker suitable for monitoring of minimal residual disease.
Martin Bornhäuser   +17 more
doaj   +1 more source

Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia

open access: yesHaematologica, 2009
Background Thalassemia major can be cured with allogeneic hematopoietic stem cell transplantation. Persistent mixed chimerism develops in around 10% of transplanted thalassemic patients, but the biological mechanisms underlying this phenomenon are poorly
Giorgia Serafini   +10 more
doaj   +1 more source

Immune Reconstitution Kinetics following Intentionally Induced Mixed Chimerism by Nonmyeloablative Transplantation. [PDF]

open access: yesPLoS ONE, 2015
Establishing mixed chimerism is a promising approach for inducing donor-specific transplant tolerance. The establishment and maintenance of mixed chimerism may enable long-term engraftment of organ transplants while minimizing the use of ...
Nayoun Kim   +9 more
doaj   +1 more source

Characterization of Tolerance Induction through Prenatal Marrow Transplantation: The Requirement for a Threshold Level of Chimerism to Establish Rather than Maintain Postnatal Skin Tolerance

open access: yesCell Transplantation, 2010
Hematopoietic chimerism resulting from prenatal marrow transplantation does not consistently result in allotolerance for unidentified causes. In a C57BL/6-into-FVB/N murine model, we transplanted T-cell-depleted adult marrow on gestational day 14 to ...
Jeng-Chang Chen M.D.   +8 more
doaj   +1 more source

Drawback of chimerism analysis by XY-fluorescence in situ hybridization: Deception of a relapse

open access: yesIndian Journal of Medical and Paediatric Oncology, 2020
Chimerism is monitored by various methods in posttransplant patients. Interphase fluorescence in situ hybridization (FISH) for XY (sex) chromosomes is one of the methods commonly employed.
D VS Kiran Kumar   +1 more
doaj   +1 more source

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