Results 161 to 170 of about 2,376,843 (237)

Clarifying Public Policy for Stronger Public Administration in Development

Public Administration and Development, EarlyView.
ABSTRACT Public policy is ubiquitous, yet its meaning is often unclear. This ambiguity is not just conceptual. Because policy work is a large part of what public administrations do, how we define policy shapes how we structure and organize our administrative mechanisms.
Matt Andrews
wiley   +1 more source

Transcriptome Inference and Systematic Approaches to Investigate TCM Compounds With Beneficial Metabolic Effects

Phytotherapy Research, EarlyView.
ABSTRACT Obesity is a major risk factor for type 2 diabetes. Some traditional Chinese medicine (TCM) compounds can improve obesity by increasing energy consumption. This study aimed to identify and verify TCM compounds that promote adipose thermogenesis to alleviate obesity via transcriptomic analysis, molecular docking, network pharmacology, and ...
Jing Li, Yang‐Chi‐Dung Lin, Hsi‐Yuan Huang, Jihang Chen, Huali Zuo, Yun Tang, Hsien‐Da Huang   +6 more
wiley   +1 more source

Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis

Phytotherapy Research, EarlyView.
BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo, Fansu Meng, Detang Li, Maciej Mazur, Alicia Marcelina Díaz García, Mulazim Hussain Asim, Zhong Chen, Yiqi Chen, Yixuan Lin, Zhenjiang Yang, Panpan Wang, Yu Cai   +11 more
wiley   +1 more source

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source

Social Sustainability in Circular Bioeconomy Business Models: Insights From Argentina

Sustainable Development, EarlyView.
ABSTRACT Research on circular bioeconomy business models (CBEBM) has largely prioritised environmental and economic aspects, leaving out the social pillar. To address this gap, this paper analyses to what extent and in what ways social sustainability is integrated into CBEBM, based on 12 cases from northern Argentina, a region with high potential for ...
Celina N. Amato, Mónica Buraschi, Karen M. Siegel   +2 more
wiley   +1 more source

The Circular Economy in European Union Supply Chains: A Literature Review

Sustainable Development, EarlyView.
ABSTRACT This research aims to analyze the implementation of the circular economy (CE) in European Union (EU) supply chains (SC), highlighting its potential to transform production systems and maximize resource efficiency while minimizing waste. Our study identifies the major trends and advancements in this field, focusing on the barriers that prevent ...
Luis Oswaldo Rodríguez‐Mañay, Inmaculada Guaita‐Pradas, Inmaculada Marques‐Perez   +2 more
wiley   +1 more source

Regional Sustainability Assessment Under Risk and Uncertainty: A Water–Energy–Food Based Framework

Sustainable Development, EarlyView.
ABSTRACT Regional sustainability assessment requires integrated structures that can examine the interactions between Water–Energy–Food (WEF) systems, socio‐economic risk conditions, and performance outcomes under uncertainty. This study proposes a multidimensional framework that combines a suitability index, composite sustainability indicators ...
Murat Oturakci
wiley   +1 more source

Mapping the Thematic Landscape of Digitalisation and Regional Sustainable Development: A Bibliometric Analysis

Sustainable Development, EarlyView.
ABSTRACT Digitalisation has become an increasingly prominent topic in research on regional sustainable development. As academic attention to its relationship with Sustainable Development Goals expands, the thematic configuration and structural evolution of this research domain remain fragmented.
Georgiana Alina Crisan, Amalia Cristescu, Madalina Ecaterina Popescu, Anda Belciu   +3 more
wiley   +1 more source