Results 41 to 50 of about 615,569 (304)

Spinocerebellar ataxia type 36 in the Han Chinese [PDF]

Neurology Genetics, 2016
To ascertain the genetic and clinical characteristics of the GGCCTG hexanucleotide repeat expansion in the nucleolar protein 56 gene (NOP56) in patients with spinocerebellar ataxia (SCA), sporadic ataxia, or amyotrophic lateral sclerosis (ALS) in Taiwan.We conducted clinical and molecular genetic studies of 109 probands with molecularly unassigned SCA ...
Lee, Yi-Chung, Tsai, Pei-Chien, Guo, Yuh-Cherng, Hsiao, Cheng-Tsung, Liu, Guan-Ting, Liao, Yi-Chu, Soong, Bing-Wen   +6 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Paternal heritage of the Han Chinese in Henan province (Central China): high diversity and evidence of in situ Neolithic expansions

Annals of Human Biology, 2020
Background: Due to their long history, complex admixture processes and large population sizes, more research is required to explore the fine genetic structure of Han populations from different geographic locations of China.
Qi Lu, Hui-Zhen Cheng, Li Li, Hong-Bin Yao, Kai Ru, Shao-Qing Wen, Mei-Sen Shi, Zhao-Shu Zeng, Lan-Hai Wei   +8 more
doaj   +1 more source

China`s xinjiang policy: an analysis based on the theory of relative deprivation [PDF]

, 2011
Xinjiang, which is China’s western province that comprised 18 percent of the country’s total land area and heavily populated by non-Han Chinese ethnic minorities, is a region increasingly beset by the problem of confrontation between two very distinct ...
Nur Shahadah Jamil,
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Circular Polarization in Pulsar Integrated Profiles: Updates

, 2006
We update the systematic studies of circular polarization in integrated pulse profiles by Han et al (1998). Data of circular polarization profiles are compiled.
Biggs J D, Crawford F, Gil J A, Gould D M, Hamilton P A, Han J L, Jin-lin Han, Kramer M, Kramer M, Lommen A N, Lyne A G, Macquart J P, Manchester R N, Manchester R N, McCulloch P M, Melrose D, Navarro J, Petrova S A, Qiao G J, Qiao G J, Radhakrishnan V, Roberts M S E, Stairs I H, van Ommen T D, von Hoensbroech A, von Hoensbroech A, Weisberg J M, Weisberg J M, Xiao-Peng You, Xilouris K M, Xu R X   +30 more
core   +1 more source

Analysis of CYP3A4 genetic polymorphisms in Han Chinese [PDF]

Journal of Human Genetics, 2011
Our study aimed to comprehensively investigate the genetic polymorphisms of CYP3A4 in Han Chinese. We sequenced the gene regions of CYP3A4, including its promoter, exons, surrounding introns and 3' untranslated region (3'UTR), from 100 unrelated-healthy Han Chinese individuals. We detected 11 SNPs, three of which are novel.
Qing, Zhou, Xiaomin, Yu, Chang, Shu, Yimei, Cai, Wei, Gong, Xumin, Wang, Duen-mei, Wang, Songnian, Hu   +7 more
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

LMO1 Gene Polymorphisms Reduce Neuroblastoma Risk in Eastern Chinese Children: A Three-Center Case-Control Study

Frontiers in Oncology, 2018
Background: Neuroblastoma, a neuroendocrine tumor, stems from the developing sympathetic nervous system. Previous genome-wide association studies (GWASs) have discovered a number of neuroblastoma susceptibility genes in Caucasians including LIM domain ...
Lili He, Jinhong Zhu, Fei Han, Yingzi Tang, Chunlei Zhou, Jincheng Dai, Yizhen Wang, Haixia Zhou, Jing He, Haiyan Wu   +9 more
doaj   +1 more source

A potential marker DYF371 for differentiating han population from non-han population in Chinese

Journal of Forensic Science and Medicine, 2020
DYF371 locus and single-nucleotide polymorphisms (SNPs) defined as DYF371C or DYF371T were simultaneously examined for 142 Chinese unrelated male individuals, including 90 Han population and 52 minorities.
Hailun Nan, Dejian Lu
doaj   +1 more source