Results 61 to 70 of about 615,569 (304)

RHC genotyping in Chinese Han population

, 2023
Abstract The Rh blood group is a complex, polymorphic system with 56 antigens. Accurately predicting the presence of the C antigen using genotyping methods has been challenging. This study aimed to evaluate different genotyping methods for C predicting and identifying associated genetic variations in the Chinese Han population.
Lin-Nan Shao, Zi-Wei Zheng, Shi-Hang Zhou, Shu-Ting Zhang, Wen-Qian Song, Yue-Xin Xia, Xiao-Hua Liang   +6 more
openaire   +1 more source

Ancestry Informative Marker Set for Han Chinese Population [PDF]

G3 Genes|Genomes|Genetics, 2012
Abstract The population of Han Chinese is ∼1.226 billion people. Genetic heterogeneity between northern Han Chinese (N-Han) and southern Han Chinese (S-Han) has been demonstrated by recent genome-wide studies. As an initial step toward health disparities and personalized medicine in Chinese population, this study developed a set of ...
Qu, Hui-Qi, Li, Quan, Xu, Shuhua, McCormick, Joseph B., Fisher-Hoch, Susan P., Xiong, Momiao, Qian, Ji, Jin, Li   +7 more
openaire   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients [PDF]

, 2017
Objective To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs.
Auce, Pauls, Avbersek, Andreja, Baum, Larry, Becker, Felicitas, Brodie, Martin J., Canadian Pharmacogenomics Network for Drug Safety, Carleton, Bruce C., Cavalleri, Gianpiero L., Cendes, Fernando, Cherny, Stacey, Coppola, Antonietta, Delanty, Norman, Depondt, Chantal, EPIGEN Consortium, EpiPGX Consortium, Francis, Ben, Gudmundsson, Lárus J., Gui, Hongsheng, Heggeli, Kristin, Ingason, Andrés, International League Against Epilepsy Consortium on Complex Epil, Johnson, Michael R., Klein, Karl Martin, Koeleman, Bobby P.C., Krause, Roland, Krenn, Martin, Kunz, Wolfram S., Kwan, Patrick, Kwok, Maxwell, Langley, Sarah R., Lerche, Holger, Leu, Costin, Liao, Wei-ping, Lopes-Cendes, Iscia, Marson, Anthony G., McCormack, Mark, O'Brien, Terence J., Pirmohamed, Munir, Rau, Sarah, Ross, Colin J.D, Sander, Josemir W., Secolin, Rodrigo, Shear, Neil, Sills, Graeme J., Sisodiya, Sanjay M., Speed, Doug, Stefánsson, Kári, Striano, Pasquale, Weckhuysen, Sarah, Wolking, Stefan, Wright, Galen E.B., Yasuda, Clarissa, Zara, Federico, Zhang, Eunice J.   +53 more
core   +7 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Polymorphism of CONNEXIN37 gene is a risk factor for ischemic stroke in Han Chinese population

Lipids in Health and Disease, 2018
Background Stroke has a high fatality and disability rate, and is one of the main burdens to human health. It is thus very important to identify biomarkers for the development of effective approaches for the prevention and treatment of stroke. Connexin37
Hong Li, Shasha Yu, Rui Wang, Zhaoqing Sun, Xinghu Zhou, Liqiang Zheng, Zhihua Yin, Yingxian Sun   +7 more
doaj   +1 more source

Body weights in Han Chinese populations

Chinese Science Bulletin, 2014
The body weights of 26,954 Han Chinese adults in 67 areas (16,503 in rural areas and 10,451 in urban areas) across China were measured from 2009 to 2013. The results showed that in China, the three areas (north China, northeast China, and Jianghuai Plain) were with the greatest body weight. Northwest Han Chinese populations were heavier.
Yonglan Li, Lianbin Zheng, Huanjiu Xi, Keli Yu, Shunhua Lu, Jinyuan Tian, Xue Song, Jinping Bao, Yuling Li, Xinghua Zhang, Youfeng Wen, Fu Ren   +11 more
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Not performing an OGTT results in underdiagnosis, inadequate risk assessment and probable cost increases of (pre)diabetes in Han Chinese over 40 years: a population-based prospective cohort study

Endocrine Connections, 2018
Objective: To explore the influence by not performing an oral glucose tolerance test (OGTT) in Han Chinese over 40 years. Design: Overall, 6682 participants were included in the prospective cohort study and were followed up for 3 years.
Xiang Hu, Qiao Zhang, Tian-Shu Zeng, Jiao-Yue Zhang, Jie Min, Sheng-Hua Tian, Hantao Huang, Miaomiao Peng, Nan Zhang, Mengjiao Li, Qing Wan, Fei Xiao, Yan Chen, Chaodong Wu, Lu-Lu Chen   +14 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source